Short-term impact of comprehensive strengthening intervention on individuals with impaired fasting glucose

郭黎; 魏平; 张忠辉; 梁瑞凯; 赵小兰

您当前的位置：

首页 >

文章列表页 >

Short-term impact of comprehensive strengthening intervention on individuals with impaired fasting glucose

更新时间：2026-01-09

- Short-term impact of comprehensive strengthening intervention on individuals with impaired fasting glucose
- Journal of Army Medical University Vol. 31, Issue 24, Pages: 2482-2485(2009)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：
  CLC： R163;R587.105;R977.15
- Published：2009
- 稿件说明：
移动端阅览
郭黎,魏平,张忠辉,梁瑞凯,赵小兰.综合强化干预对空腹血糖受损人群的近期影响[J].陆军军医大学学报(原第三军医大学学报),2009,31(24):2482-2485.

　GUO Li,WEI Ping,ZHANG Zhong-hui,LIANG Rui-kai,ZHAO Xiao-lan.Short-term impact of comprehensive strengthening intervention on individuals with impaired fasting glucose[J].J Amry Med Univ (J Third Mil Med Univ),2009,31(24):2482-2485.
郭黎,魏平,张忠辉,梁瑞凯,赵小兰.综合强化干预对空腹血糖受损人群的近期影响[J].陆军军医大学学报(原第三军医大学学报),2009,31(24):2482-2485. DOI：

　GUO Li,WEI Ping,ZHANG Zhong-hui,LIANG Rui-kai,ZHAO Xiao-lan.Short-term impact of comprehensive strengthening intervention on individuals with impaired fasting glucose[J].J Amry Med Univ (J Third Mil Med Univ),2009,31(24):2482-2485. DOI：

摘要

目的探讨在生活方式改善的基础上用罗格列酮钠对空腹血糖受损（impaired fasting glucose，IFG）患者进行综合强化干预治疗的效果。方法将137例空腹血糖受损患者随机分成单纯生活方式干预组（健康教育+饮食+运动，n=68）和综合强化方式干预组（罗格列酮钠+运动+饮食，n=69），观察6个月。监测、对比、分析两组患者体质量指数（body mass index

BMI）、腰臀比(waist-hip ratio，WHR）、总胆固醇（total cholesterol

TC）、甘油三酯（total glycerin，TG）、低密度脂蛋白胆固醇（low density lipoprotein cholesterol

LDL-C）、高密度脂蛋白胆固醇(high density lipoprotein cholesterol

HDL-C)、血尿酸（uric acid

UA）、空腹血糖(fasting plasma glucose

FPG)、餐后2 h血糖（postprandial 2 hours plasma glucose

2 hPG）、空腹胰岛素(fasting insulin

FINS)，餐后2 h胰岛素（2 hours fasting insulin

2 hINS），糖化血红蛋白（glycohemoglobin，HbA1c），并2 h/NS进一步计算胰岛素分泌指数(insulin secretion index，HOMA-IS)和胰岛素抵抗指数(insulin resistance index，HOMA-IR)等指标。结果 ①综合强化干预组的患者，在干预治疗6 个月后，TC、TG、LDL-C、UA、FPG、2hPG、FINS、HbA1c等明显下降（P0.05）；②生活方式干预组患者在坚持饮食控制和体育运动治疗6 个月后，BMI、WHR、TC、TG、LDL-C、FPG、2hPG、FINS、HbA1c等有一定下降趋势（P0.05）。结论对IFG 患者在接受健康教育的基础上控制饮食、坚持运动，给予罗格列酮钠进行干预治疗是更有积极意义的。

Abstract

Objective To determine whether rosiglitazone sodium can be used to increase insulin sensitive and improve glucose tolerance in individuals with impaired fasting glucose (IFG) on the basis of rational diet and exercise. Methods Totally 137 patients with IFG was divided into 2 groups randomly

lifestyle intervention group (n=68)

and the comprehensive strengthening intervention group (rosiglitazone sodium

4 mg/d

n=69). The period of observation was 6 months. The observed items included: the body mass index (BMI)

fasting plasma glucose (FPG)

postprandial 2-hour plasma glucose (2hPG)

total cholesterol (TC)

total glycerin (TG)

high density lipoprotein cholesterol (HDL-C)

low density lipoprotein cholesterol (LDL-C )

fasting insulin (FINS)

and glycohemoglobin (HbA1c) were measured. And insulin secretion index (HOMA-IS) and insulin resistance index (HOMA-IR) were calculated. Results After 6 months treatment

we found that FPG

2hPG

LDL-C

FINS and HbA1c were decreased sharply in the comprehensive strengthening intervention group compared with the values of these parameters before treatment (P0.05). After 6 months’ rational diet and exercise

the lifestyle intervention group had little declined BMI

WHR

LDL-C

FPG

2hPG

FINS and HbA1c in compared with before intervention (P0.05). There was no any adverse effect or side effect observed. Conclusion It is recommendable to administer rosiglitazone sodium to the patients with IFG on the basis of rational diet and exercise.

关键词

Keywords

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Growing burden of atherosclerotic cardiovascular disease in China: An analysis on lifestyle and metabolic factors based on the Global Burden of Disease Study 2021

Deferoxamine suppresses neuronal damage in T1DM rats by reducing cerebral iron content

A mathematical model to estimate mean blood glucose by oral glucose tolerance test

Mitochondrial dynamics in the pathogenesis of diabetic complications

Analysis of influencing factors for serum procalcitonin level in septic patients

Related Author

TU Qiuyue

PENG Xinyu

HE Ziyi

LIN Derong

LIU Jianhua

LIANG Jingrong

CI Yunzhe

LI Haiyan

Related Institution

Guangzhou University of Chinese Medicine

Pingshan Hospital of Traditional Chinese Medicine

Dongguan Hospital， Guangzhou University of Chinese Medicine

Department of Histology and Embryology， Affiliated Hospital， Chengde Medical University

Department of Human Anatomy， Affiliated Hospital， Chengde Medical University

⁰