Synthesis and craftsmanship optimization of R-modafinil

卢来春; 卢华; 王朝安; 胡小刚; 赵艳艳; 孟德胜

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Synthesis and craftsmanship optimization of R-modafinil

更新时间：2026-01-09

- Synthesis and craftsmanship optimization of R-modafinil
- Journal of Army Medical University Vol. 31, Issue 23, Pages: 2361-2362(2009)
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  CLC： R916.4;R971.7
- Published：2009
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卢来春,卢华,王朝安,胡小刚,赵艳艳,孟德胜.R-莫达非尼的合成及条件优化[J].陆军军医大学学报(原第三军医大学学报),2009,31(23):2361-2362.

　LU Lai-chun,LU Hua,WANG Chao-an,HU Xiao-gang,ZHAO Yan-yan,MENG De-sheng.Synthesis and craftsmanship optimization of R-modafinil[J].J Amry Med Univ (J Third Mil Med Univ),2009,31(23):2361-2362.
卢来春,卢华,王朝安,胡小刚,赵艳艳,孟德胜.R-莫达非尼的合成及条件优化[J].陆军军医大学学报(原第三军医大学学报),2009,31(23):2361-2362. DOI：

　LU Lai-chun,LU Hua,WANG Chao-an,HU Xiao-gang,ZHAO Yan-yan,MENG De-sheng.Synthesis and craftsmanship optimization of R-modafinil[J].J Amry Med Univ (J Third Mil Med Univ),2009,31(23):2361-2362. DOI：

摘要

目的合成R-莫达非尼，并对合成条件进行优化。方法以二苯甲醇为原料，与2-巯基乙酸反应合成2-二苯甲基硫代乙酸，再经成酯保护、H

氧化、脱保护、拆分，最后氨化合成R-莫达非尼。结果合成了目标化合物，结构经旋光仪、

C NMR、

H NMR、IR分析确证，总收率为10.1%。结论合成思路和路线切实可行。

Abstract

Objective To synthesize R-modafinil and optimize the synthetic route. Methods Target molecule R-modafinil was synthesized from diphenylmethanol and mercapto-acetic acid by a six-step reaction

including condensation

esterification

oxidation

deprotection

split

and ammonification. Results The target molecule was synthesized and identified by spectropolarimeter

C NMR

H NMR

and IR. The total yield was 10.1%. Conclusion Our synthesis of R-modafinil is accomplished with a feasible synthetic route. 

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