Expression of Bcl-2 and calretinin in dysplasia enteric ganglion cells of hirschsprung patients

朱进; 金先庆

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Expression of Bcl-2 and calretinin in dysplasia enteric ganglion cells of hirschsprung patients

更新时间：2026-01-09

- Expression of Bcl-2 and calretinin in dysplasia enteric ganglion cells of hirschsprung patients
- Journal of Army Medical University Vol. 32, Issue 1, Pages: 60-62(2010)
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  CLC： R725.74;R394.3;R341
- Published：2010
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朱进,金先庆.Bcl-2、钙视网膜蛋白在发育异常肠壁神经节细胞中的表达[J].陆军军医大学学报(原第三军医大学学报),2010,32(01):60-62.

　Zhu Jin,Jin Xianqing.Expression of Bcl-2 and calretinin in dysplasia enteric ganglion cells of hirschsprung patients[J].J Amry Med Univ (J Third Mil Med Univ),2010,32(01):60-62.
朱进,金先庆.Bcl-2、钙视网膜蛋白在发育异常肠壁神经节细胞中的表达[J].陆军军医大学学报(原第三军医大学学报),2010,32(01):60-62. DOI：

　Zhu Jin,Jin Xianqing.Expression of Bcl-2 and calretinin in dysplasia enteric ganglion cells of hirschsprung patients[J].J Amry Med Univ (J Third Mil Med Univ),2010,32(01):60-62. DOI：

摘要

目的探讨Bcl-2和钙视网膜蛋白（calretinin，CR）在不同发育程度肠壁神经节细胞中的表达及意义。方法采用免疫组织化学染色观察Bcl-2、CR在40例先天性巨结肠病(hirschsprung disease

HD)、10例先天性巨结肠类缘病(hirschsprung’s allied disease

HAD)和对照组肠壁神经节细胞的表达情况。结果 Bcl-2表达于发育较差的神经节细胞，在发育成熟的神经节细胞不表达。CR表达于发育成熟的神经节细胞，在发育较差的神经节细胞不表达或弱表达。 结论 Bcl-2和CR在肠神经节细胞的特异性表达，有助于判断神经节细胞的成熟程度。Bcl-2在发育异常肠壁神经节细胞的功能维持和恢复上可能起到了重要作用。

Abstract

Objective To explore the expression of Bcl-2 and calretinin (CR）in enteric ganglion cells in different developmental conditions and its significance. Methods The immunohistochemical staining was carried out to detect the expression of Bcl-2 and CR in enteric ganglion cells at different intestinal segments from tissue samples of 40 hirschsprung disease (HD) cases (age

26 d to 12 years old)

10 Hirschsprung’s allied disease (HAD) cases and 10 normal controls. Results In immature ganglion cells

there was a strong expression of Bcl-2

and no positive to or poor expression of CR. In mature ganglion cells

there was a strong expression of CR but no positive Bcl-2 staining. Conclusion The specific expression of Bcl-2 and CR may play an essential role in judging if the ganglion cells are mature. Bcl-2 might be of importance in the maintenance and restore of the fuction of enteric immature ganglion cells.

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