Clinical significance of pulse dye densitometry in effective hepatic blood flow detection

李昆; 冯晓彬; 林恒; 郑平; 张玉君; 郑树国

您当前的位置：

首页 >

文章列表页 >

Clinical significance of pulse dye densitometry in effective hepatic blood flow detection

更新时间：2026-01-09

- Clinical significance of pulse dye densitometry in effective hepatic blood flow detection
- Journal of Army Medical University Vol. 31, Issue 23, Pages: 2358-2360(2009)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：
  CLC： R197.39;R322.47;R735.7
- Published：2009
- 稿件说明：
移动端阅览
李昆,冯晓彬,林恒,郑平,张玉君,郑树国.脉动色素浓度测定法检测有效肝脏血流量对肝病患者的临床意义[J].陆军军医大学学报(原第三军医大学学报),2009,31(23):2358-2360.

　LI Kun,FENG Xiao-bin,LIN Heng,ZHENG Ping,ZHANG Yu-jun,ZHENG Shu-guo.Clinical significance of pulse dye densitometry in effective hepatic blood flow detection[J].J Amry Med Univ (J Third Mil Med Univ),2009,31(23):2358-2360.
李昆,冯晓彬,林恒,郑平,张玉君,郑树国.脉动色素浓度测定法检测有效肝脏血流量对肝病患者的临床意义[J].陆军军医大学学报(原第三军医大学学报),2009,31(23):2358-2360. DOI：

　LI Kun,FENG Xiao-bin,LIN Heng,ZHENG Ping,ZHANG Yu-jun,ZHENG Shu-guo.Clinical significance of pulse dye densitometry in effective hepatic blood flow detection[J].J Amry Med Univ (J Third Mil Med Univ),2009,31(23):2358-2360. DOI：

摘要

目的介绍一种肝储备功能与肝脏有效血流量（effective hepatic blood flow， EHBF）的检测方法，探讨其临床意义。方法采用脉动色素浓度测定法（pulse dye densitometry， PDD）和传统的分光光度仪比色法同时检测９２例患者吲哚菁绿（indocyanine green

ICG）15 min滞留率（ICGR

），分析检测结果的相关性；采用ＰＤＤ法检测1 181例肝癌、85例门脉高压和120例肝血管瘤患者ICGR

、ICG清除率（K）、全身血容量（BV）、心输出量（CO）及EHBF。结果 PDD测定法检测的ICGR

与分光光度仪比色法的测定结果显著相关（y=0.789x+2.109，r=0.945，P0.01）。肝癌和门脉高压患者EHBF较肝血管瘤组显著降低，ICGR

和CO显著升高。ICGR

值小于10%的肝癌患者EHBF平均为1.233 L/min，EHBF随着ICGR

的升高显著降低；60岁以上肝癌患者K值、CO和EHBF较60岁以下组均显著降低。结论脉动色素浓度测定法具有无创、实时、便捷等优点，检测的各项数据对评估肝储备功能和EHBF，把握手术方式和范围有一定的参考价值。

Abstract

Objective To introduce a new method for measuring hepatic reserve function and effective hepatic blood flow (EHBF)

and to assess its clinical significance. Methods The correlation between indocyanine green retention rate at 15 min (ICGR

) measured by pulse dye densitometry (PDD) and spectrophotometry was analyzed in 92 patients. 1181 patients with hepatocellular carcinoma (HCC)

85 patients with portal hypertension and 120 patients with hepati

c hemangioma were enrolled in this study. ICGR

plasma dye clearance rate (K)

blood volume (BV)

cardiac output (CO) and EHBF were detected by PDD. Results ICGR

measured by spectrophotometry in vitro in blood samples was significantly correlated with that obtained by PDD method （y=0.789x+2.109

r=0.945

P0.01）. EHBF obtained from patients with HCC or portal hypertension were obviously lower than those from patients with hepatic hemangioma

but ICGR

and CO in the two groups were higher than those in the hepatic hemangioma group. The mean value of EHBF from patients with HCC was 1.233 L/min when ICGR

was less than 10%. EHBF decreased with the increase of ICGR

. K

CO and EHBF in HCC patients above the age of 60 were significantly lower than those in patients below the age of 60. Conclusion PDD is a kind of noninvasive

realtime and convenient approach to assess hepatic reserve function and EHBF

which is helpful for surgeons to decide the range of operation.

关键词

Keywords

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

ETS1 transcription up-regulates FBXO45 and promotes invasion and migration of hepatocellular carcinoma via epithelial-mesenchymal transition

miR-576-5p regulates the EMT process to inhibit migration and invasion of hepatocellular carcinoma cells

Bilirubin impairs the sorafenib sensitivity in Huh7 cells through fatty acid oxidation by up-regulating PPARα/CPT1A

HBx promotes liver tumor in mice by inhibiting microRNA-145a-5p

Hepatitis B virus X promotes tumorigenesis of hepatocellular carcinoma through HIPPO signaling pathway in mice

Related Author

ZHU Zhenbao

WU Feifan

GU Yongpeng

XIE Chuanming

ZHANG Leida

崔琦

王余彦

卢映君

Related Institution

Department of Hepatobiliary Surgery， First Affiliated Hospital， Army Medical University （Third Military Medical University）

Department of Hepatobiliary Surgery， the Second Affiliated Hospital of Chongqing Medical University

⁰