Differences between acute lung injury induced by immersion in seawater and in freshwater in dogs after open chest trauma

胡晓红; 段蕴铀; 李毅; 薛志强; 孟继光

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Differences between acute lung injury induced by immersion in seawater and in freshwater in dogs after open chest trauma

更新时间：2026-01-09

- Differences between acute lung injury induced by immersion in seawater and in freshwater in dogs after open chest trauma
- Journal of Army Medical University Vol. 31, Issue 21, Pages: 2090-2093(2009)
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  CLC： R563;R655;R835.3
- Published：2009
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胡晓红,段蕴铀,李毅,薛志强,孟继光.胸部开放伤后海水和淡水浸泡对肺损伤的作用比较[J].陆军军医大学学报(原第三军医大学学报),2009,31(21):2090-2093.

　HU Xiao-hong,DUAN Yun-you,LI Yi,XUE Zhi-qiang,MENG Ji-guang.Differences between acute lung injury induced by immersion in seawater and in freshwater in dogs after open chest trauma[J].J Amry Med Univ (J Third Mil Med Univ),2009,31(21):2090-2093.
胡晓红,段蕴铀,李毅,薛志强,孟继光.胸部开放伤后海水和淡水浸泡对肺损伤的作用比较[J].陆军军医大学学报(原第三军医大学学报),2009,31(21):2090-2093. DOI：

　HU Xiao-hong,DUAN Yun-you,LI Yi,XUE Zhi-qiang,MENG Ji-guang.Differences between acute lung injury induced by immersion in seawater and in freshwater in dogs after open chest trauma[J].J Amry Med Univ (J Third Mil Med Univ),2009,31(21):2090-2093. DOI：

摘要

目的比较胸部开放伤后胸腔海水与淡水浸泡对肺损伤的作用。方法 24只实验犬致胸部开放伤后分成对照组、海水组和淡水组。海水组和淡水组伤后10 min内经伤口分别灌入海水和淡水；观察胸部开放伤后0、2、4、6、8 h的生命体征，测渗透压、血浆炎症因子变化。伤后8 h取肺组织观察病理学和炎症因子变化。结果肺泡通透指数: 海水组较淡水组明显升高（P0.05），淡水组与对照组比较无统计学差异（P0.05）；IL-1β、IL-8: 海水组较淡水组升高（P0.05），淡水组较对照组升高（P0.05）；血管性血友病因子(von Willnbrang factor

vWf):海水组较淡水组、对照组升高（P0.05），淡水组较对照组无差异。相关分析显示：血浆渗透压与肺泡通透性指数、炎症因子IL-1β、IL-8正相关（P0.05）。结论海水较淡水对开放伤后肺组织的损伤程度更严重，可能与海水高渗加重肺血管通透性和过度炎症反应有关。

Abstract

Objective To compare the differences between acute lung injury (ALI) induced by seawater-immersion and freshwater-immersion after open chest trauma. Methods Twenty-four dogs were randomly divided into 3 groups

ALI model group (control)

seawater immersion group (group SW)

and freshwater immersion group (group FW). ALI model was established by cutting an incision of 0.5 cm at the 4th intercostal space. Then artificial seawater or pure water (35 ml/kg) was perfused into the incision for the later 2 groups. The pathological changes were evaluated by light microscopy

hemotoxin and eosin (HE) staining in 8 h after perfusion. In 0

6 and 8 h after trauma

the plasma samples were collected to test the levels of IL-1β

IL-8 and von Willnbrang factor (vWF) with ELISA. The amount of total protein in plasma and bronchoalveolar lavage fluid (BALF) were measured. Results Compared with group FW

the pulmonary penetration index

the concentrations of IL-1β

IL-8 and vWF in the plasma and lung tissue in group SW were markedly higher. They were significantly positively correlated with the plasma osmotic pressure (P0.05). Conclusion Despite immersing in seawater and in freshwater worsen the ALI after open chest trauma

the ALI induced by seawater-immersion is severer than that caused by freshwater-immersion. It is attributed to higher plasma osmo-tic pressure and abundance of salts after seawater immersion

which increasing the pulmonary penetration index and aggravating the inflammatory response.

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