Reduced frequency of CD4<sup>+</sup> central memory T cells in patients with tuberculosis

牛翰婕; 程小星; 王心静; 曹志红; 董梅; 佟爱华

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Reduced frequency of CD4⁺ central memory T cells in patients with tuberculosis

更新时间：2026-01-09

- Reduced frequency of CD4⁺ central memory T cells in patients with tuberculosis
- Journal of Army Medical University Vol. 31, Issue 16, Pages: 1549-1551(2009)
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  CLC： R392.12;R392.32;R52
- Published：2009
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牛翰婕,程小星,王心静,曹志红,董梅,佟爱华.结核抗原特异性CD4+中央型记忆T细胞的检测及分布特性研究[J].陆军军医大学学报(原第三军医大学学报),2009,31(16):1549-1551.

　NIU Han-jie,CHENG Xiao-xing,WANG Xin-jing,CAO Zhi-hong,DONG Mei,TONG Ai-hua.Reduced frequency of CD4+ central memory T cells in patients with tuberculosis[J].J Amry Med Univ (J Third Mil Med Univ),2009,31(16):1549-1551.
牛翰婕,程小星,王心静,曹志红,董梅,佟爱华.结核抗原特异性CD4+中央型记忆T细胞的检测及分布特性研究[J].陆军军医大学学报(原第三军医大学学报),2009,31(16):1549-1551. DOI：

　NIU Han-jie,CHENG Xiao-xing,WANG Xin-jing,CAO Zhi-hong,DONG Mei,TONG Ai-hua.Reduced frequency of CD4+ central memory T cells in patients with tuberculosis[J].J Amry Med Univ (J Third Mil Med Univ),2009,31(16):1549-1551. DOI：

摘要

目的比较活动期肺结核患者和纯蛋白衍生物（purified protein derivative，PPD）试验阳性健康人记忆T细胞的产生和分布特性。方法取乙二胺四乙酸（ethylene diamine tetraacetic acid，EDTA）抗凝静脉血，Ficoll进行密度梯度离心获取PBMCs。采用卡介苗刺激后，通过CD4、CD154、CCR7、CD45RA 4种抗体共染色，用流式细胞仪检测结核抗原特异性CD4

记忆T细胞。结果以CD4

CD154

双阳性区设门，研究结核抗原特异性CD4+记忆T细胞，结果显示，肺结核患者CD4+CD154

CD45RA

CCR7

中央型T淋巴细胞亚群分布频率显著降低（P0.05），CD4

CD154

CD45RA

CCR7

初始T细胞亚群的比例明显增高（P0.05）。结论肺结核患者CD4

中央型记忆T淋巴细胞亚群的产生存在异常，可能与免疫功能低下和结核病发病密切相关。

Abstract

Objective To compare the production and population frequency of mycobacterial antigen-specific CD4

memory T cells in patients with pulmonary tuberculosis (TB) and normal individuals with positive purified protein derivative (PPD

). Methods PBMCs were isolated from TB patients and PPD

normal human peripheral blood and stimulated with Bacillus Calmette Guerin (BCG). Memory T cells were investigated with surface staining of CD4

CD154

CCR7

and CD45RA and flow cytometry. Re

sults Compared with PPD

normal individuals

patients with pulmonary tuberculosis had significantly reduced frequency of CD4

CD154

CD45RA

CCR7

central memory T cells subsets (P0.05) and elevated frequency of CD4

CD154

CD45RA

CCR7

naive T cells subsets (P0.05). Conclusion Reduced frequency of central memory T cells subsets in pulmonary tuberculosis might play an important role in the development of tuberculosis.

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Reduced frequency of CD4+ central memory T cells in patients with tuberculosis

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摘要

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Reduced frequency of CD4⁺ central memory T cells in patients with tuberculosis