Myelination of rat brain at different developmental stages

张雨平; 黄其林; 赵聪敏; 汤金梁; 王亚丽

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Myelination of rat brain at different developmental stages

更新时间：2026-01-09

- Myelination of rat brain at different developmental stages
- Journal of Army Medical University Vol. 31, Issue 22, Pages: 2189-2192(2009)
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  CLC： R-332;R322.81;R339.3
- Published：2009
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张雨平,黄其林,赵聪敏,汤金梁,王亚丽.不同发育阶段大鼠脑髓鞘化的研究[J].陆军军医大学学报(原第三军医大学学报),2009,31(22):2189-2192.

　ZHANG Yu-ping,HUANG Qi-lin,ZHAO Cong-min,TANG JIN-liang,WANG Ya-li.Myelination of rat brain at different developmental stages[J].J Amry Med Univ (J Third Mil Med Univ),2009,31(22):2189-2192.
张雨平,黄其林,赵聪敏,汤金梁,王亚丽.不同发育阶段大鼠脑髓鞘化的研究[J].陆军军医大学学报(原第三军医大学学报),2009,31(22):2189-2192. DOI：

　ZHANG Yu-ping,HUANG Qi-lin,ZHAO Cong-min,TANG JIN-liang,WANG Ya-li.Myelination of rat brain at different developmental stages[J].J Amry Med Univ (J Third Mil Med Univ),2009,31(22):2189-2192. DOI：

摘要

目的研究大鼠不同发育阶段脑髓鞘化的发展及规律。方法应用LFB髓鞘染色、MBP免疫组化及Wes-tern blot观察不同发育阶段大鼠脑髓鞘的分布及变化。结果 LFB及MBP免疫组化染色E18、P0、P2均未见着色，P7大鼠胼胝体中部少量LFB着色，P15两种染色均呈阳性，P30着色加深，与P90、P720类似。通过Western blot检测MBP蛋白在孕中后期已有表达，出生后随日龄增长逐渐增加，至老年期表达量最高。结论大鼠脑髓鞘化从P15已经开始，P30接近成熟；观察髓鞘的最佳时间在30 d以后。

Abstract

Objective To investigate the myelination of rat brain at different developmental stages. Methods Luxol fast blue staining

immunohistochemistry and Western blotting were applied to determine the distribution and alternation of myelin sheath in the brains of SD rats at different developmental stages. Results Negative LFB and MBP staining were shown at the stages of embryonicage 18 d (E18)

postnatal age 0 d (P0) and P2. At P7

the corpus callosum was weakly stained by LFB. The positive stain of LFB and MBP occurred in P15 on the corpus callosum. With the development going on

the stain turned out stronger

especially in P30

which was similar with that in P90 and P720. The results of Western blot analysis showed the expression of MBP in rat brain was gradually increased with the development of rat brain. Conclusion The myelination starts before P15 in rat brain and becomes mature in P30. The optimal observation time of myelin is 30 d born after.

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