Downregulation of P2X<sub>7</sub> receptor expression in neonatal rats after hypoxic-ischemic brain damage

王丽雁; 蔡文琴; 陈鹏慧

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Downregulation of P2X₇ receptor expression in neonatal rats after hypoxic-ischemic brain damage

更新时间：2026-01-09

- Downregulation of P2X₇ receptor expression in neonatal rats after hypoxic-ischemic brain damage
- Journal of Army Medical University Vol. 31, Issue 22, Pages: 2171-2174(2009)
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  CLC： R363.27;R741.02;R743.31
- Published：2009
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王丽雁,蔡文琴,陈鹏慧.P2X7受体在新生大鼠缺氧缺血性脑损伤后表达下调[J].陆军军医大学学报(原第三军医大学学报),2009,31(22):2171-2174.

　WANG Li-yan,CAI Wen-qin,CHEN Peng-hui.Downregulation of P2X7 receptor expression in neonatal rats after hypoxic-ischemic brain damage[J].J Amry Med Univ (J Third Mil Med Univ),2009,31(22):2171-2174.
王丽雁,蔡文琴,陈鹏慧.P2X7受体在新生大鼠缺氧缺血性脑损伤后表达下调[J].陆军军医大学学报(原第三军医大学学报),2009,31(22):2171-2174. DOI：

　WANG Li-yan,CAI Wen-qin,CHEN Peng-hui.Downregulation of P2X7 receptor expression in neonatal rats after hypoxic-ischemic brain damage[J].J Amry Med Univ (J Third Mil Med Univ),2009,31(22):2171-2174. DOI：

摘要

目的了解P2X

受体在新生大鼠缺氧缺血型脑损伤后的表达变化。方法选择出生7 d的SD大鼠建立新生鼠缺氧缺血性脑损伤模型，通过Western blot和免疫组化检测缺氧缺血前后脑皮层、白质、海马P2X

受体表达。结果缺氧缺血后2 h，患侧皮层、白质和海马P2X

受体蛋白较假手术对照组明显下调（P0.05，P0.01）；免疫组化也显示患侧皮层、白质和海马P2X

受体表达下降。结论 P2X

受体可能参与了新生鼠缺氧缺血性脑损伤过程。

Abstract

Objective To investigate the change of P2X

receptor expression in neonatal rats after hypoxic-ischemic brain damage (HIBD). Methods Twenty SD rats were randomized into 2 groups

control group and hypoxic-ischemic (HI) group. Western blotting and immunohistochemistry was used to detect the protein expression of P2X

receptor in cerebal cortex

subcortical white matter and hippocampus before and after hypoxia-ischemia. Results In comparison to the sham operation controls

a significant down-regulation of the P2X

receptor protein was observed in ischemic cerebral cortex

subcortical white matter (P0.05) and hippocampus (P0.01) of ischemic hemisphere 2 h after hypoxia ischemia. A substantial loss of ipsilatera

l P2X

R immunostaining in the lateral corpus callosum

adjacent cortex

and hippocampus was observed in comparison to the controls. Conclusion The post-ischemic downregulation of P2X

R indicates a role for this receptor in the pathophysiology of hypoxic-ischemic brain injury.

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Department of Histology， Embryology and Neurobiology， West China School of Basic Medical Sciences and Forensic Medicine， Sichuan University

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Downregulation of P2X7 receptor expression in neonatal rats after hypoxic-ischemic brain damage

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Downregulation of P2X₇ receptor expression in neonatal rats after hypoxic-ischemic brain damage