Determination of droxidopa in human plasma and pharmacokinetic features

钟玲; 邱妍川; 尚京川

您当前的位置：

首页 >

文章列表页 >

Determination of droxidopa in human plasma and pharmacokinetic features

更新时间：2026-01-09

- Determination of droxidopa in human plasma and pharmacokinetic features
- Journal of Army Medical University Vol. 31, Issue 11, Pages: 1112-1114(2009)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：
  CLC： R927.2;R969.1;R977.1
- Published：2009
- 稿件说明：
移动端阅览
钟玲,邱妍川,尚京川.人血浆中屈昔多巴的测定及药代动力学研究[J].陆军军医大学学报(原第三军医大学学报),2009,31(11):1112-1114.

　ZHONG Ling,QIU Yan-chuan,SHANG Jing-chuan.Determination of droxidopa in human plasma and pharmacokinetic features[J].J Amry Med Univ (J Third Mil Med Univ),2009,31(11):1112-1114.
钟玲,邱妍川,尚京川.人血浆中屈昔多巴的测定及药代动力学研究[J].陆军军医大学学报(原第三军医大学学报),2009,31(11):1112-1114. DOI：

　ZHONG Ling,QIU Yan-chuan,SHANG Jing-chuan.Determination of droxidopa in human plasma and pharmacokinetic features[J].J Amry Med Univ (J Third Mil Med Univ),2009,31(11):1112-1114. DOI：

摘要

目的建立测定人血浆中屈昔多巴的方法，并应用于药代动力学研究。方法 12例健康受试者单剂量口服屈昔多巴胶囊200 mg后，血样经高氯酸沉淀蛋白，通过HPLC-荧光检测法测定屈昔多巴的浓度，并运用3P87分析软件计算其药代动力学参数。结果屈昔多巴测定的线性范围为0.025～2 μg/ml，其主要的药动学参数T

1/2

108.50±30.78)min，曲线下峰面积（AUC） (185.74±26.41)μg·ml

-1

·min

-1

，消除率（CL）(1.08±0.08)ml/min，T

max

(99.90±10.05)min，C

max

（0.74±0.08)μg/ml，服药10 h后屈昔多巴几乎从血液中完全消除。结论本方法灵敏度高，重现性好，操作简便，可用于血浆样品中屈昔多巴的定性定量检测；屈昔多巴在体内的药代动力学过程符合二室模型。

Abstract

Objective To propose a method for the determination of droxidopa concentration in human plasma by HPLC method for the study of the pharmacokinetics of droxidopa. Methods After a single oral dose of 200 mg droxidopa capsule was administered to 12 healthy Chinese male volunteers

we used perchloric acid to precipitate proteinum and then determined the droxidopa concentration in plasma by HPLC. The pharmacokinetic parameters of droxidopa were calculated by 3P87 software. Results The linear range was 0.025-2 μg/ml. Pharmacokinetic parameters were: T

1/2

(108.50±30.78)min

AUC (185.74±26.41) μg·ml

-1

·min

-1

CL (1.08±0.08)ml/

min

max

(99.90±10.05)min

max

(0.74±0.08)μg/ml. At 10 h after administration

droxidopa was eliminated from the blood almost completely. Conclusion The method we proposed is sensitive

reproducible

and easy to operate. Pharmacokinetics of droxidopa in vivo is fitted to two-compartment model.

关键词

Keywords

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Single-dose and multiple-dose pharmacokinetics of levofloxacin in Chinese healthy subjects

Pharmacokinetics and pharmacodynamics of injectable dex-rabrazole for healthy people

Pharmacokinetic study of ranolazine in Chinese healthy volunteers

Pharmacokinetics and pharmacodynamics of pantoprazole sodium at different doses in healthy volunteers

Determination of ginsenoside Rg3 in rat plasma using highperformance liquid chromatographytandem mass spectrometry

Related Author

郁继诚

张菁

曹国英

郭蓓宁

武晓捷

施耀国

张婴元

喻明洁

Related Institution

No data

⁰