Objective   To evaluate the safety and effectiveness of a modified transvaginal total pelvic floor reconstruction with self-trimmed mesh in female pelvic organ prolapse (POP).    Methods   Totally 58 women with identified POP and underging the reconstruction in our department from June 2007 to July 2008 were analyzed retrospectively. These patients

at the age ranging from 42 to 82

had gravidity of 1 to 9 times

parity of 1 to 8 time

and time of prolapse of 1 to 360 months. According to the POP quantitation (POP-Q). there were 22 cases of stage Ⅳ

20 of stage Ⅲ; 10 of stage Ⅱ; and 6 of stage Ⅰin anterior vaginal wall prolapse; 26 of stage Ⅳ

12 of stage Ⅲ

13 of stage Ⅱ and 7 of stage Ⅰin uterine prolapse; 18 of stage Ⅳ

15 of stage Ⅲ

11 of stage Ⅱ

8 of stage Ⅰ and 6 of stage 0 in posterior vaginal wall prolapse. Five patients complicated with stress urinary incontinence. All patients undertook the total pelvic floor reconstruction using trimmed mesh to substitute Prolift.    Results   The mean operation time was 114±40 min (59 to 200)

and the mean blood loss was 138±90 ml (50 to 400). After the surgery

the mean time of indwelling urethral catheter was 2.5±0.6 d (2 to 4)

and the mean post-operative hospital stay was 3.5±1.4 d (4 to 8). No complication was observed during and after the surgery. No bladder

rectum and urethra was injured. During the follow-up of 6 to 12 months

all patients except 2 (3.5%) reported satisfaction with the therapeutic results. The average scores of the pelvic floor impact questionnaire (PFIQ) was dropped dramatically from preoperatively 81.2±28.9 to postoperatively 15.3±8.3

and the average scores of the sexual function questionnaire (PISQ) had no significant difference (66.6±9.1 preoperatively

68.0±8.4 postoperatively). During follow-up

2 patients were found to have asymptomatic erosion (3.4%). With regard to the simultaneous correction of the urine incontinence

all the patients was successful. No case of urine incontinence was observed after the procedure.    Conclusion   Our modified transvaginal total pelvic floor reconstruction is safe

cheaper and easy to perform with a low rate of postoperative relapse and complications

and  it is an effective approach for POP repair. However

long-term efficiency still need further follow-up and observation.