Expressions of Livin α and Livin β in marrow mononuclear cells of childhood acute leukemia and the clinical significance

毛成刚; 郭玥馨; 罗庆; 徐酉华

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Expressions of Livin α and Livin β in marrow mononuclear cells of childhood acute leukemia and the clinical significance

更新时间：2026-01-09

- Expressions of Livin α and Livin β in marrow mononuclear cells of childhood acute leukemia and the clinical significance
- Journal of Army Medical University Vol. 31, Issue 15, Pages: 1488-1490(2009)
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  CLC： R394.3;R730.43;R733.71
- Published：2009
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毛成刚,郭玥馨,罗庆,徐酉华.Livinα和Livinβ在儿童急性白血病骨髓单个核细胞中的表达及临床意义[J].陆军军医大学学报(原第三军医大学学报),2009,31(15):1488-1490.

　MAO Cheng-gang,GUO Yue-xin,LUO Qing,XU You-hua.Expressions of Livin α and Livin β in marrow mononuclear cells of childhood acute leukemia and the clinical significance[J].J Amry Med Univ (J Third Mil Med Univ),2009,31(15):1488-1490.
毛成刚,郭玥馨,罗庆,徐酉华.Livinα和Livinβ在儿童急性白血病骨髓单个核细胞中的表达及临床意义[J].陆军军医大学学报(原第三军医大学学报),2009,31(15):1488-1490. DOI：

　MAO Cheng-gang,GUO Yue-xin,LUO Qing,XU You-hua.Expressions of Livin α and Livin β in marrow mononuclear cells of childhood acute leukemia and the clinical significance[J].J Amry Med Univ (J Third Mil Med Univ),2009,31(15):1488-1490. DOI：

摘要

目的研究Livinα和Livinβ在儿童急性白血病（childhood acute leukemia，CAL）骨髓单个核细胞（marrow mononuclear cell，MMNC）中的表达与临床意义。方法采用实时PCR（real-time PCR）和Western blot检测Livinα和Livinβ在CAL骨髓单个核细胞中mRNA水平和蛋白质水平的表达。结果 Livinα和Livinβ在初诊的39例儿童急性淋巴细胞白血病（acute lymphoblastic leukemia，ALL）和12例急性髓细胞白血病（acute myeloid leukemia，AML）MMNC中的表达率和表达水平均高于对照组（P0.05），Livinα的表达水平高于Livinβ（P0.01）。ALL化疗后第19天，幼稚细胞≤5%组Livinα和Livinβ的表达水平较化疗前明显降低（P0.01）。幼稚细胞＞5%组化疗后较化疗前也降低（P0.05），但化疗后Livinα和Livinβ的表达水平仍明显高于对照组（P0.01）。结论 Livinα和Livinβ在CAL中高表达可能对评估CAL临床危险度及预后有重要意义；提示Livinα和Livinβ可作为观察CAL预后的分子指标之一。

Abstract

Objective To investigate the expressions of Livin α and Livin β in marrow mononuclear cells (MMNCs) of childhood acute leukemia (CAL) and explore the clinical significance. Methods Real-time quantitative PCR and Western blot were used to detect the mRNA and protein expressions of Livin α and Livin β in MMNCs of CAL

respectively. Results Both Livinα and Livinβ expression rates and expression levels were higher in preliminary diagnosis group（n=51）of CAL ，including acute lymphoblastic leukemia（n=39）and acute myeloid leukemia （n=12)

compared with the control group（P0.05）

and the expression level of Livinα was higher than Livinβ（P0.01）. The expression levels of Livinα and Livinβ were significantly lower in patients with a favorable day 19 bone marrow response (leukemic blasts ≤5%) to induction chemotherapy of ALL than in the patients without chemotherapy（P0.01）. Though the expression levels of Livinα and Livinβ were also lower in patients with a unfavorable day 19 bone marrow response (leukemic blasts＞5%) to induction chemotherapy of ALL than in the patients without chemotherapy（P0.05）

the expression levels of Livinα and Livinβ were still significantly higher than that of the control group（P0.01）. Conclusion The expression of Livinα and Livinβ may be associated with the genesis and development of CAL. It seems that the expression of Livinα and Livinβ may be used as a molecular marker of CAL.

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