Endoglin in assessing angiogenesis of epithelial ovarian tumor: report of 70 cases

王丹; 梁志清; 徐惠成; 陈勇

您当前的位置：

首页 >

文章列表页 >

Endoglin in assessing angiogenesis of epithelial ovarian tumor: report of 70 cases

更新时间：2026-01-09

- Endoglin in assessing angiogenesis of epithelial ovarian tumor: report of 70 cases
- Journal of Army Medical University Vol. 31, Issue 10, Pages: 945-947(2009)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：
  CLC： R730.23;R730.43;R737.31
- Published：2009
- 稿件说明：
移动端阅览
王丹,梁志清,徐惠成,陈勇.Endoglin在评价卵巢上皮性肿瘤血管生成中的意义[J].陆军军医大学学报(原第三军医大学学报),2009,31(10):945-947.

　WANG Dan,LIANG Zhi-qing,XU Hui-cheng,CHEN Yong.Endoglin in assessing angiogenesis of epithelial ovarian tumor: report of 70 cases[J].J Amry Med Univ (J Third Mil Med Univ),2009,31(10):945-947.
王丹,梁志清,徐惠成,陈勇.Endoglin在评价卵巢上皮性肿瘤血管生成中的意义[J].陆军军医大学学报(原第三军医大学学报),2009,31(10):945-947. DOI：

　WANG Dan,LIANG Zhi-qing,XU Hui-cheng,CHEN Yong.Endoglin in assessing angiogenesis of epithelial ovarian tumor: report of 70 cases[J].J Amry Med Univ (J Third Mil Med Univ),2009,31(10):945-947. DOI：

摘要

目的探讨Endoglin在卵巢上皮性肿瘤血管生成中的意义。方法采用免疫组织化学方法，对本院2000年12月至2003年12月手术切除的70例卵巢上皮肿瘤标本分别标记CD34和Endoglin，并分别进行微血管密度（microvessel density，MVD）计数。结果 CD34标记的MVD在良性和恶性卵巢上皮性肿瘤间无统计学差异（P0.05），而Endoglin标记的MVD在良性和恶性肿瘤间差异有统计学意义(P0.05)；恶性卵巢上皮性肿瘤临床Ⅰ～Ⅱ期CD34和Endoglin标记的MVD均高于Ⅲ～Ⅳ期；CD34标记的MVD在恶性卵巢上皮性肿瘤病理分级Ⅰ、Ⅱ、Ⅲ级间无统计学差异（P0.05），而病理分级Ⅲ级Endoglin标记的MVD明显高于Ⅰ～Ⅱ级。结论 Endoglin标记计数的MVD优于CD34、CD31和Von Willebrand因子等标记的MVD，可作为肿瘤血管生成状态的评价指标。

Abstract

Objective To investigate the significance of endoglin in the angiogenesis of ovarian carcinoma. Methods Immunohistochemical assay was used to investigate 70 tissue samples of pathologically identified epithelial ovarian tumor (including 31 specimen of benign and 39 of malignant) from December 2000 to December 2003 in our department using monoclonal antibodies against CD34 and endoglin. Microvessels density (MVD) was counted by experienced pathologists. Results No significant difference of MVD for CD34 was observed in the ovarian cystadenoma and ovarian carcinoma. In contrast

an increment of MVD for endoglin from low-grade to high-grade dysplasia and that from earlier stage to later stage was statistically significant. Conclusion Endoglin may be a valuable marker for assessing neovascularization in the process of ovarian carcinoma development and for predicting the risk of ovarian carcinoma development.

关键词

Keywords

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Molecular mechanism of invasion inhibitory effects of genistein on human ovarian serous papillary cystadenocarcinoma cell SKOV₃

Screening of conjugated peptides of Endoglin from phage display peptide library

Related Author

李昱

米粲

毕仙民

梁志清

侍立峰

Related Institution

No data

⁰