Objective   To investigate the bladder function alterations after inflammatory stimulation to cervix through observing urodynamic parameters in rats.    Methods   A total of 36 adult female Sprague-Dawley (SD) rats were randomly assigned into 2 groups

cervicitis group (n=24) and control (n=12). The cervicitis model was established by intravaginal injection of 0.1 ml 25% phenol mucilage

once in 2 d for 5 times

and the rats of control group receiving an intravaginal injection of normal saline. Cervical tissue samples were collected after the model establishment. The filling cystometry was performed before and after the stimulation in each group.    Results   (1) In the control group

the basic pressure

per-micturition pressure

micturition pressure

vesical volume and vesical compliance were not significantly changed (P0.05)

and there was no significant difference in instable contraction occurring at filling period. As compared with those before stimulation

the cervicitis model group had increased basic pressure and per-micturition pressure  and significantly decreased micturition pressure

vesical volume and vesical compliance lowered (P0.01)

and micturition contractions were inhibited. Among them

66.67% rats experienced instable contractions at filling period. (2) In the rats before stimulation

the difference of urodynamic indexes had no significance in the rats stimulated with the phenol mucilage and with the normal saline (P0.05)

but the changes were significant after stimulation (P0.01).    Conclusion   The inflammatory stimulus to cervix causes bladder function changes in rats

but the underlying mechanism need to be further studied.