Correlation between the polymorphism of matrix metalloproteinase-9 and esophageal squamous cell carcinoma patients in Southwest China

傅勇; 胡华梅; 谭益; 唐胜军; 熊刚; 杨康; 白云

您当前的位置：

首页 >

文章列表页 >

Correlation between the polymorphism of matrix metalloproteinase-9 and esophageal squamous cell carcinoma patients in Southwest China

更新时间：2026-01-09

- Correlation between the polymorphism of matrix metalloproteinase-9 and esophageal squamous cell carcinoma patients in Southwest China
- Journal of Army Medical University Vol. 31, Issue 12, Pages: 1131-1134(2009)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：
  CLC： R394.3;R730.23;R735.1
- Published：2009
- 稿件说明：
移动端阅览
傅勇,胡华梅,谭益,唐胜军,熊刚,杨康,白云.基质金属蛋白酶-9基因多态性与食管鳞状细胞癌易感性的关联研究[J].陆军军医大学学报(原第三军医大学学报),2009,31(12):1131-1134.

　FU Yong,HU Hua-mei,TAN Yi,TANG Sheng-jun,XIONG Gang,YANG Kang,BAI Yun.Correlation between the polymorphism of matrix metalloproteinase-9 and esophageal squamous cell carcinoma patients in Southwest China[J].J Amry Med Univ (J Third Mil Med Univ),2009,31(12):1131-1134.
傅勇,胡华梅,谭益,唐胜军,熊刚,杨康,白云.基质金属蛋白酶-9基因多态性与食管鳞状细胞癌易感性的关联研究[J].陆军军医大学学报(原第三军医大学学报),2009,31(12):1131-1134. DOI：

　FU Yong,HU Hua-mei,TAN Yi,TANG Sheng-jun,XIONG Gang,YANG Kang,BAI Yun.Correlation between the polymorphism of matrix metalloproteinase-9 and esophageal squamous cell carcinoma patients in Southwest China[J].J Amry Med Univ (J Third Mil Med Univ),2009,31(12):1131-1134. DOI：

摘要

目的研究基质金属蛋白酶-9(matrix metalloproteinsase-9，MMP-9)基因多态性与中国西南地区人群食管鳞状细胞癌(esophageal squamous cell carcinoma，ESCC)的关联性。方法应用聚合酶链反应-限制性片段长度多态性(polymerase chain reaction-restriction fragment length polymorphisms，PCR-RFLPs)方法检测235例食管鳞状细胞癌病例组及300例健康对照组的MMP-9 R279Q基因多态性的分布情况。结果 ESCC患病组和健康对照组MMP-9 279R、279Q等位基因频率分别为57.7%、42.3%和51.5%、48.5%，二者有显著性差异(χ

=4.08，P=0.04)；MMP-9 279R/R基因型频率在ESCC病例组(40.5%)中显著高于对照组(29.0%)(χ

=20.08，P=0.01)；当按年龄进行分层分析时，与Q/Q基因型相比，R/R基因型能明显增加50岁以下人群ESCC的发病风险(校正OR值为3.39，95%CI为1.23～9.29)。结论携带有MMP-9 279R等位基因的人群与ESCC易感性有显著关联性，MMP-9 279R/R基因型可增加患ESCC的风险。在中国西南地区人群中MMP-9 R279Q基因多态性可能是ESCC发生的危险因素之一。

Abstract

Objective To investigate the correlation between the single nucleotide polymorphism (SNP) of Matrix metalloproteinsase-9 (MMP-9) gene and esophageal squamous cell carcinoma patients in Southwest China. Methods The polymerase chain reaction-restriction fragment length polymorphisms (PCR-RFLPs) technique was applied to analyze the MMP-9 R279Q polymorphism in normal group (300) an

d ESCC group (235). Results Frequencies of the MMP-9 279R and 279Q allele distribution in ESCC patients and healthy control were 57.7%

42.3% and 51.5%

48.5%

respectively (χ

=4.08

P=0.04). The frequency of the R/R genotype in the MMP-9 gene polymorphism increased significantly in ESCC patients (40.5%) as compared with that in the controls (29.0%) (χ

=20.08

P=0.01). Age-stratified analysis showed R/R genotype significantly increased the risk of ESCC in individuals younger than 50 years (adjusted OR=3.39

95%CI=1.23~9.29). Conclusion The R allele of MMP-9 gene R279Q might be associated with the increased susceptibility to ESCC. The R homozygote might increase the risk of ESCC. Our results indicated that MMP-9 R279Q polymorphism might be associated with genetic susceptibility to ESCC in Southwest Chinese population.

关键词

Keywords

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Correlation of copy number variation of Variation_91720 in PIK3CA gene with susceptibility of esophageal squamous cell carcinoma: a report of 149 patients from Southwest China

Association of polymorphism of STAT3 gene with susceptibility Kawasaki disease in Chongqing, China

Construction of machine learning-based prognostic model of centrosome amplification-related genes for esophageal squamous cell carcinoma

Association of Rab37 gene polymorphism and delayed menarche: a report of 2 060 women

Association between single nucleotide polymorphism of BMAL1 and bipolar disorder

Related Author

刘曦

吴园园

张坤

陶桓晟

官兴颖

杨康

钟芳芳

蒋利萍

Related Institution

Department of Gastroenterology， Second Affiliated Hospital， Army Medical University （Third Military Medical University）

Department of Epidemiology， Faculty of Military Preventive Medicine， Army Medical University （Third Military Medical University）

Department of Disease Control and Prevention， General Hospital of Western Theater Command

College of Public Health， Southwest Medical University

⁰