Expression of cathepsin L in hepatocellular carcinoma

晋云; 董家鸿

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Expression of cathepsin L in hepatocellular carcinoma

更新时间：2026-01-09

- Expression of cathepsin L in hepatocellular carcinoma
- Journal of Army Medical University Vol. 30, Issue 22, Pages: 2139-2141(2008)
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  CLC： R394.3;R730.2;R735.7
- Published：2008
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晋云,董家鸿.肝细胞癌cathepsin L表达分析[J].陆军军医大学学报(原第三军医大学学报),2008,30(22):2139-2141.

　JIN Yun,DONG Jia-hong.Expression of cathepsin L in hepatocellular carcinoma[J].J Amry Med Univ (J Third Mil Med Univ),2008,30(22):2139-2141.
晋云,董家鸿.肝细胞癌cathepsin L表达分析[J].陆军军医大学学报(原第三军医大学学报),2008,30(22):2139-2141. DOI：

　JIN Yun,DONG Jia-hong.Expression of cathepsin L in hepatocellular carcinoma[J].J Amry Med Univ (J Third Mil Med Univ),2008,30(22):2139-2141. DOI：

摘要

目的探讨cathepsin L蛋白在肝细胞癌中的表达及其与肿瘤临床病理特征的关系。方法 58例肝细胞癌中病理分级高分化18例、中分化18例、低分化22例；临床分期Ⅰ＋Ⅱ期26例、Ⅲ+Ⅳ期32例。采用免疫组织化学染色、RT-PCR法检测cathepsin L表达，结合患者临床病理指标及预后进行分析。结果 cathepsin L表达阳性率为72.4％（42/58），不同病理分级、临床分期及转移分组cathepsin L表达阳性率差异显著。cathepsin L mRNA检出阳性率65.5％（38/58），cathepsin L mRNA的表达与肝细胞癌的病理分级、临床分期及淋巴转移有相关性。结论 cathepsin L 在肝细胞癌的生长浸润、侵袭转移中发挥重要作用，可作为肝细胞癌预后判断的客观指标之一。

Abstract

Objective To explore the expression of cathepsin L in hepatocellular carcinoma and to analyze its relationship with clinical and pathological features. Methods Fifty-eight specimens of hepatocellular carcinoma were studied

including 18 well-differentiated

18 moderately differentiated and 22 poorly differentiated. Classified by TNM clinical stage

26 were in Ⅰ/Ⅱ stage and 32 in Ⅲ/Ⅳ stage. The expressions of cathepsin L were detected with immunohistochemistry and RT-PCR. Their relationship with the clinical and pathological features of hepatocellular carcinoma was analyzed. Results The positive rate of cathepsin L protein was 72.4% (42/58)

and the expressions of cathepsin L protein were significantly different among the specimens of pathological grades of tumor

of TNM clinical stages and with/without metastasis. The positive rate of cathepsin L mRNA was 65.5% (38/58). The expression of cathepsin L mRNA in hepatocellular carcinoma was correlated with pathological grades of tumor

TNM clinical stages and lymph node metastasis. Conclusion Cathepsin L plays an important role in the occurrence of hepatocellular carcinoma for its correlation with infiltration and metastasis of hepatocellular carcinoma. Cathepsin L can be used as a useful marker for the prognosis of hepatocellular carcinoma patients.

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