Expression and clinical significance of EphB4 in breast infiltrating ductal carcinoma: report of 65 cases

杨光伦; 涂刚; 姚榛祥; 岳俊伊

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Expression and clinical significance of EphB4 in breast infiltrating ductal carcinoma: report of 65 cases

更新时间：2026-01-09

- Expression and clinical significance of EphB4 in breast infiltrating ductal carcinoma: report of 65 cases
- Journal of Army Medical University Vol. 31, Issue 5, Pages: 438-440(2009)
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  CLC： R730.21;R730.43;R737.9
- Published：2009
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杨光伦,涂刚,姚榛祥,岳俊伊.EphB4在乳腺浸润性导管癌中的表达及意义[J].陆军军医大学学报(原第三军医大学学报),2009,31(05):438-440.

　YANG Guang-lun,TU Gang,YAO Zhen-xiang,YUE Jun-yi.Expression and clinical significance of EphB4 in breast infiltrating ductal carcinoma: report of 65 cases[J].J Amry Med Univ (J Third Mil Med Univ),2009,31(05):438-440.
杨光伦,涂刚,姚榛祥,岳俊伊.EphB4在乳腺浸润性导管癌中的表达及意义[J].陆军军医大学学报(原第三军医大学学报),2009,31(05):438-440. DOI：

　YANG Guang-lun,TU Gang,YAO Zhen-xiang,YUE Jun-yi.Expression and clinical significance of EphB4 in breast infiltrating ductal carcinoma: report of 65 cases[J].J Amry Med Univ (J Third Mil Med Univ),2009,31(05):438-440. DOI：

摘要

目的探讨EphB4在乳腺浸润性导管癌中的表达及临床意义。方法采用免疫组织化学S-P法检测65例浸润性导管癌以及12例癌旁乳腺组织中的EphB4、ER、PR、CerBb-2、P53的表达。结果 EphB4在65例乳腺浸润性导管癌中的表达明显高于癌旁乳腺组织（P0.05）， EphB4的表达与CerBb-2及肿瘤组织学分级呈正相关（P0.05）；与ER、PR及淋巴结转移无相关性(P0.05)。结论 EphB4在乳腺癌的发展中起着重要作用。

Abstract

Objective To study the expression and clinical significance of EphB4 in breast infiltrating ductal carcinoma. Methods SP immunohistochemical technique was used to examine the expression of EphB4 in 65 cases of breast infiltrating ductal cancer and 12 matched adjacent tissue samples. Results The level of EphB4 in breast infiltrating ductal cancer was significantly higher than that of adjacent normal tissues (P0.01). EphB4 expression had a positive correlation with histological grade and CerBb-2 (P0.05)

but not with ER

PR and metastasis (P0.05). Conclusion EphB4 plays a crucial role in the occurrence and development of breast cancer.

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