Effect of Fosinopril on oxidative stress of pancreatic tissue in diabetic rats

闫纪强; 刘东方; 周厚地; 徐鑫

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Effect of Fosinopril on oxidative stress of pancreatic tissue in diabetic rats

更新时间：2026-01-09

- Effect of Fosinopril on oxidative stress of pancreatic tissue in diabetic rats
- Journal of Army Medical University Vol. 31, Issue 2, Pages: 160-162(2009)
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  CLC： R322.491;R587.1;R972
- Published：2009
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闫纪强,刘东方,周厚地,徐鑫.福辛普利对糖尿病大鼠胰腺组织氧化应激的影响[J].陆军军医大学学报(原第三军医大学学报),2009,31(02):160-162.

　YAN Ji-qiang,LIU Dong-fang,ZHOU Hou-di,XU Xin.Effect of Fosinopril on oxidative stress of pancreatic tissue in diabetic rats[J].J Amry Med Univ (J Third Mil Med Univ),2009,31(02):160-162.
闫纪强,刘东方,周厚地,徐鑫.福辛普利对糖尿病大鼠胰腺组织氧化应激的影响[J].陆军军医大学学报(原第三军医大学学报),2009,31(02):160-162. DOI：

　YAN Ji-qiang,LIU Dong-fang,ZHOU Hou-di,XU Xin.Effect of Fosinopril on oxidative stress of pancreatic tissue in diabetic rats[J].J Amry Med Univ (J Third Mil Med Univ),2009,31(02):160-162. DOI：

摘要

目的研究糖尿病大鼠胰腺组织氧化应激的情况及福辛普利干预后胰岛功能及胰腺组织的免疫组化改变。方法 21只大鼠分对照组、糖尿病组、福辛普利干预组，糖尿病组用高脂进行喂养制作糖尿病模型，干预组喂以福辛普利(5 mg/kg)，在病程不同时点测定血糖、体质量及胰腺组织中硝基酪氨酸的含量，并观察胰腺组织免疫组化改变。结果糖尿病组与正常对照组胰腺硝基酪氨酸含量比较明显增高（P0.01）；福辛普利干预组与糖尿病组胰腺中硝基酪氨酸含量比较明显降低，氧化应激水平亦降低（P0.05）。结论糖尿病大鼠胰腺组织的氧化应激存在异常，福辛普利对糖尿病大鼠胰腺氧化应激存在抑制作用。

Abstract

Objective To study the oxidative stress in diabetic rat pancreas

and the changes of islet function after intervention of Fosinopril. Methods Wistar rats were randomly divided into control group

diabetes group and Fosinopril treated group. The diabetes was induced by feeding the rats from diabetes group and Fosinopril group with high fat diet for 3 weeks and then once intraperitoneal injection of STZ (35 mg/kg)

while additionally Fosinopril (5 mg/kg) was given to the diabetic rats in Fosinopril treated group. Blood glucose

body weight

nitrotyrosine levels in pancreatic tissues were detected and the histopathologic changes of pancreatic tissues were observed. Results Nitrotyrosine content was significantly higher in diabetes group than that in control group (P0.01). Nitrotyrosine content and the level of oxidative stress were significantly decreased in Fosinopril treated group compared with those in diabetes group (P0.05). Conclusion Nitrotyrosine content is abnormal in diabetic rats

and Fosinopril can significantly inhibit the oxidative stress in pancreas.

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