Cardiac myocyte damage in fetus of rabbits with intrahepatic cholestasis pregnant

冯丽霞; 李力; 俞丽丽; 郑英如; 郭建新; 易萍; 颜耀华

您当前的位置：

首页 >

文章列表页 >

Cardiac myocyte damage in fetus of rabbits with intrahepatic cholestasis pregnant

更新时间：2026-01-09

- Cardiac myocyte damage in fetus of rabbits with intrahepatic cholestasis pregnant
- Journal of Army Medical University Vol. 31, Issue 4, Pages: 334-337(2009)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：
  CLC： R-332;R542.2;R714.255
- Published：2009
- 稿件说明：
移动端阅览
冯丽霞,李力,俞丽丽,郑英如,郭建新,易萍,颜耀华.妊娠肝内胆汁淤积症胎兔心肌细胞损伤的研究[J].陆军军医大学学报(原第三军医大学学报),2009,31(04):334-337.

　FENG Li-xia,LI Li,YU Li-li,ZHENG Ying-ru,GUO Jian-xin,YI Ping,YAN Yao-hua.Cardiac myocyte damage in fetus of rabbits with intrahepatic cholestasis pregnant[J].J Amry Med Univ (J Third Mil Med Univ),2009,31(04):334-337.
冯丽霞,李力,俞丽丽,郑英如,郭建新,易萍,颜耀华.妊娠肝内胆汁淤积症胎兔心肌细胞损伤的研究[J].陆军军医大学学报(原第三军医大学学报),2009,31(04):334-337. DOI：

　FENG Li-xia,LI Li,YU Li-li,ZHENG Ying-ru,GUO Jian-xin,YI Ping,YAN Yao-hua.Cardiac myocyte damage in fetus of rabbits with intrahepatic cholestasis pregnant[J].J Amry Med Univ (J Third Mil Med Univ),2009,31(04):334-337. DOI：

摘要

目的观察妊娠肝内胆汁淤积症（intrahepatic cholestasis of pregnancy，ICP）胎兔心肌细胞超微结构及细胞凋亡率，检测心肌腺苷三磷酸(ATP)、超氧化物歧化酶(SOD)、丙二醛(MDA)含量。方法 16只孕兔，分为ICP组和对照组。ICP组自妊娠第22天，颈后皮下注射苯甲酸雌二醇0.1 mg·kg

-1

·d

-1

，对照组颈后皮下注射0.9%生理盐水，直至分娩。观察ICP组和对照组胎兔心肌细胞超微结构，检测心肌细胞ATP、SOD、MDA含量及细胞凋亡指数。结果电镜观察见ICP胎兔心肌细胞线粒体轻度肿胀、髓鞘样结构形成，细胞质内糖原颗粒分布减少，对照组超微结构无明显改变。ICP组胎心组织ATP、SOD含量减少，MDA含量和细胞凋亡数明显增多，与对照组相比差异均有统计学意义（P0.05）。结论 ICP胎兔存在心肌细胞损伤。

Abstract

Objective To investigate ultrastructure and apoptotic rate of fetal cardiac myocytes of rabbits with intrahepatic cholestasis of pregnancy (ICP)and the levels of adenosine triphosphate (ATP)

superoxide dismutase (SOD) and malondialdehyde (MDA) in the myocardial tissues. Methods Sixteen pregnant rabbits were randomly divided into control group and ICP group. Rabbits in ICP group were subcutaneously injected with benzestrofol at a dose of 0.1 mg·kg

-1

·d

-1

and control group with 0.9% saline solution from the 22nd gestation day to delivery day. The levels of ATP

SOD and MDA in myocardial tissues of ICP rabbit fetuses and control fetuses were

determined. Ultrastructure and number of apoptosis cells were observed. Results Compared with controls

the levels of ATP and SOD in ICP rabbit fetuses’ cardiac myocytes significantly decreased (P0.05)

while the levels of MDA and the number of apoptosis cells in ICP rabbit fetuses’ cardiac myocytes significantly increased. Slight swelling

vacuolation and myelinoclasis in mitochondria

and decreased glycogen granules in cytoplasm were observed in ICP rabbit fetuses’ cardiac myocytes under electron microscope. However

these ultrastructural alteration was not observed in controls. Conclusion The damage of cardiac myocytes does exist in fetuses of rabbits with ICP.

关键词

Keywords

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Thrombotic thrombocytopenicpurpura during pregnancy: report of 2 cases and literature review

Continuous plasma filtration adsorption for treatment of acute pancreatitis in pregnancy: analysis of 18 cases

Anesthetic management in cesarean section in women with heart disease: analysis of 96 cases

Analysis of pregnancy outcomes in 267 nulliparous women after high-intensity focused ultrasound ablation of uterine fibroids

Analysis of perinatal outcomes in 232 adolescent primiparas

Related Author

Xiaoxia CHEN

Nannan WANG

Xiaoli YAN

Dan WANG

Qing CHANG

Yufeng DENG

Xiang CHEN

Yue HE

Related Institution

Department of Obstetrics and Gynecology, First Affiliated Hospital, Army Medical University (Third Military Medical University)

Department of Women's Healthcare, Chongqing Maternal and Child Health Hospital

Department of Hepatobiliary Surgery, Chongqing Emergency Center

Department of Critical Care Medicine, First Affiliated Hospital, Army Medical University (Third Military Medical University)

Department of Anesthesia, Second Affiliated Hospital, Army Medical University (Third Military Medical University)

⁰