Erythropoietin induces CD26 upregulation in CD34<sup>+</sup> human cord blood hemato-poietic cells

范娅涵; 宋敏; 黎儒青; 蒋天伦; 赵树铭

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Erythropoietin induces CD26 upregulation in CD34⁺ human cord blood hemato-poietic cells

更新时间：2026-01-09

- Erythropoietin induces CD26 upregulation in CD34⁺ human cord blood hemato-poietic cells
- Journal of Army Medical University Vol. 31, Issue 5, Pages: 409-411(2009)
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  CLC： R329.25;R331.14;{R392.13}
- Published：2009
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范娅涵,宋敏,黎儒青,蒋天伦,赵树铭.EPO上调人CD34+脐血干细胞CD26的表达[J].陆军军医大学学报(原第三军医大学学报),2009,31(05):409-411.

　FAN Ya-han,SONG Min,LI Ru-qing,JIANG Tian-lun,ZHAO Shu-ming.Erythropoietin induces CD26 upregulation in CD34+ human cord blood hemato-poietic cells[J].J Amry Med Univ (J Third Mil Med Univ),2009,31(05):409-411.
范娅涵,宋敏,黎儒青,蒋天伦,赵树铭.EPO上调人CD34+脐血干细胞CD26的表达[J].陆军军医大学学报(原第三军医大学学报),2009,31(05):409-411. DOI：

　FAN Ya-han,SONG Min,LI Ru-qing,JIANG Tian-lun,ZHAO Shu-ming.Erythropoietin induces CD26 upregulation in CD34+ human cord blood hemato-poietic cells[J].J Amry Med Univ (J Third Mil Med Univ),2009,31(05):409-411. DOI：

摘要

目的研究EPO对人CD34

脐血干细胞表面CD26表达的影响。方法应用流式细胞仪法检测经MACS-CD34

免疫磁珠分选并采用EPO处理后培养的人CD34

脐血干细胞，通过与酶底物反应检测人CD34

脐血造血干细胞表面CD26的表达情况。结果与对照组相比，经EPO 100 U/ml和EPO 200 U/ml 18h培养后的CD34

脐血造血干细胞群中CD26

细胞比例明显上升，其酶活性亦明显升高。结论 EPO可上调CD34

脐血干细胞表面CD26的表达并增强其生物学功能。

Abstract

Objective To observe short-term erythropoietin (EPO) treatment on the expression of CD26

dipeptidyl-peptidase Ⅳ

in the CD34

human cord blood hematopoietic cells in vitro. Methods The CD34

cells were sorted from human cord blood by magnetic activated cell sorting (MACS) technique

and subjected to recombinant human EPO treatment at a dose of 50

100 and 200 U/ml. We detected CD26 expression of the treated and non-treated cells by flow cytometry and CD26 activity by responding with chromogenic CD26 substrate Gly-Pro-p-nitoanilide. Results CD26 expression and activity increased significantly in EPO 100 and 200 U/ml treatment group. Conclusion Short-term EPO treatment

in vitro upregulates CD26 expression and activity in the CD34

human cord blood hematopoietic cells

and enhances its biological function.

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Erythropoietin induces CD26 upregulation in CD34+ human cord blood hemato-poietic cells

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Abstract

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references

Erythropoietin induces CD26 upregulation in CD34⁺ human cord blood hemato-poietic cells