Effect of an isoflavone derivative F11 on apoptosis of human breast cancer cells

尹姝心; 艾国平; 常青; 杨伟; 粟永萍

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Effect of an isoflavone derivative F11 on apoptosis of human breast cancer cells

更新时间：2026-01-09

- Effect of an isoflavone derivative F11 on apoptosis of human breast cancer cells
- Journal of Army Medical University Vol. 31, Issue 4, Pages: 315-317(2009)
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  CLC： R285.5;R730.23;R737.9
- Published：2009
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尹姝心,艾国平,常青,杨伟,粟永萍.异黄酮改构化合物F11对人乳腺癌细胞凋亡的影响及其机制研究[J].陆军军医大学学报(原第三军医大学学报),2009,31(04):315-317.

　YIN Shu-xin,AI Guo-ping,CHANG Qing,YANG Wei,SU Yong-ping.Effect of an isoflavone derivative F11 on apoptosis of human breast cancer cells[J].J Amry Med Univ (J Third Mil Med Univ),2009,31(04):315-317.
尹姝心,艾国平,常青,杨伟,粟永萍.异黄酮改构化合物F11对人乳腺癌细胞凋亡的影响及其机制研究[J].陆军军医大学学报(原第三军医大学学报),2009,31(04):315-317. DOI：

　YIN Shu-xin,AI Guo-ping,CHANG Qing,YANG Wei,SU Yong-ping.Effect of an isoflavone derivative F11 on apoptosis of human breast cancer cells[J].J Amry Med Univ (J Third Mil Med Univ),2009,31(04):315-317. DOI：

摘要

目的研究异黄酮改构化合物F11对人乳腺癌细胞凋亡的影响及其机制。方法采用DNA Ladder、DAPI细胞核染色检测F11对人乳腺癌细胞MCF-7凋亡的影响，Western blot检测凋亡相关蛋白Caspase-3、PARP、p53的表达。结果异黄酮改构化合物F11可诱导人乳腺癌细胞发生凋亡，增加Caspase-3和PARP蛋白的表达（P0.01），抑制p53蛋白的表达（P0.05，P0.01）。结论异黄酮改构化合物F11诱导MCF-7发生凋亡，可能是通过诱导Caspase-3和PARP蛋白表达的增加，抑制p53蛋白的表达实现的。

Abstract

Objective To investigate the mechanism by which an isoflavone derivative F11 affects apoptosis of human breast cancer cell line MCF-7. Methods The apoptosis of MCF-7 cells induced by F11 was detected by DNA Ladder and DAPI dyeing. Western blot assay was used to detect the protein expressions of Caspase-3

PARP and p53. Results F11 induced cell apoptosis of MCF-7. After F11 treatment

the expressions of Caspase-3 and PARP increased

and the expression of mutant p53 decreased. Conclusion Isoflavone derivative F11 induces the apoptosis of breast cancer cells through upregulating the expressions of Caspase-3 and PARP

and decreasing p53 expression.

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