Role of CK20 and CDX2 in evaluating D<sub>3</sub> lymph nodes micrometastasis

刘涛; 张超; 吕伟; 刘佳; 刘立业; 甘露

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Role of CK20 and CDX2 in evaluating D₃ lymph nodes micrometastasis

更新时间：2026-01-09

- Role of CK20 and CDX2 in evaluating D₃ lymph nodes micrometastasis
- Journal of Army Medical University Vol. 31, Issue 2, Pages: 117-119(2009)
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  CLC： R446.8;R73-37;R735.37
- Published：2009
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刘涛,张超,吕伟,刘佳,刘立业,甘露.CK20和CDX2在直肠癌D3淋巴结微转移研究中的意义[J].陆军军医大学学报(原第三军医大学学报),2009,31(02):117-119.

　LIU Tao,ZHANG Chao,LU Wei,LIU Jia,LIU Li-ye,GAN Lu.Role of CK20 and CDX2 in evaluating D3 lymph nodes micrometastasis[J].J Amry Med Univ (J Third Mil Med Univ),2009,31(02):117-119.
刘涛,张超,吕伟,刘佳,刘立业,甘露.CK20和CDX2在直肠癌D3淋巴结微转移研究中的意义[J].陆军军医大学学报(原第三军医大学学报),2009,31(02):117-119. DOI：

　LIU Tao,ZHANG Chao,LU Wei,LIU Jia,LIU Li-ye,GAN Lu.Role of CK20 and CDX2 in evaluating D3 lymph nodes micrometastasis[J].J Amry Med Univ (J Third Mil Med Univ),2009,31(02):117-119. DOI：

摘要

目的应用CK20和CDX2检测直肠癌D

淋巴结微转移的规律。方法将2006年12月至2008年6月在本科诊断为Dukes B期和Dukes C期的68例中低位直肠癌患者，分组行开腹和腹腔镜下直肠癌D

根治术，将切除的淋巴结做HE染色一抗为CDX2和CK20的免疫组化染色，判定转移和微转移情况。结果 68例病例共检出1 571枚淋巴结，平均每例23.1枚。其中，侧方淋巴结微转移者7例，占10.3%，上方淋巴结微转移者6例，占8.8%，D

淋巴结微转移共13例，占19.1%。结论通过CDX2和CK20的检测，Dukes B期和C期的中低位直肠癌患者D

淋巴结微转移的概率较大，应常规行D

根治术。

Abstract

Objective To study the rule of D

lymph node micrometastasis through detecting cytokeratin 20 (CK20) and caudal type homeobox transcription factor 2 (CDX2) in rectal cancer

and to provide an objective evidence for the application of D

radical correction for rectal cancer. Methods HE staining and immunohistochemical staining were used to analyze CK20 and CDX2 expressions in all lymph node specimens got from 68 patients

whom had been diagnosed with rectal cancer in stage B or C

and received D

radical correction for rectal cancer during December 2006 to June 2008 in Department of

General Surgical Southwest Hospital (Chongqing). Results Totally 1 5

71 lymph nodes were got from 68 patients

23.1 in average per patient. The latero-micrometastasis rate was 10.3%

upside was 8.8%

and the total metastasis rate of D

lymph nodes was 19.1%. Conclusion Through detecting CK20 and CDX2

we found that the risk of relapse and metastasis is very high in the patients whose mid-low rectal cancer is in the stage Dukes B or Dukes C

so D

radical correction for rectal cancer is quite worthy being generally applied.

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Related Institution

Department of General Surgery， First Affiliated Hospital， Army Medical University （Third Military Medical University）

Department of Clinical Nursing， First Affiliated Hospital， Army Medical University （Third Military Medical University）

Department of General Surgery， Second Affiliated Hospital， Army Medical University （Third Military Medical University）

Department of Gastrointestinal Colorectal and Anal Surgery， Army Medical Center of PLA/Daping Hospital of Third Military Medical University

Department of General Surgery， First Medical Center， Chinese PLA General Hospital， Beijing

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Role of CK20 and CDX2 in evaluating D3 lymph nodes micrometastasis

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摘要

Abstract

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Role of CK20 and CDX2 in evaluating D₃ lymph nodes micrometastasis