EphA2/EphrinA1 expressions in human gastric carcinoma and their relationship with angiogenesis

刘辉; 郭建文; 刘江惠; 左连富

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EphA2/EphrinA1 expressions in human gastric carcinoma and their relationship with angiogenesis

更新时间：2026-01-09

- EphA2/EphrinA1 expressions in human gastric carcinoma and their relationship with angiogenesis
- Journal of Army Medical University Vol. 30, Issue 23, Pages: 2183-2186(2008)
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  CLC： R392-33;R730.23;R735.2
- Published：2008
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刘辉,郭建文,刘江惠,左连富.EphA2/EphrinA1在胃癌组织中的表达及与血管生成的关系[J].陆军军医大学学报(原第三军医大学学报),2008,30(23):2183-2186.

　LIU Hui,GUO Jian-wen,LIU Jiang-hui,ZUO Lian-fu.EphA2/EphrinA1 expressions in human gastric carcinoma and their relationship with angiogenesis[J].J Amry Med Univ (J Third Mil Med Univ),2008,30(23):2183-2186.
刘辉,郭建文,刘江惠,左连富.EphA2/EphrinA1在胃癌组织中的表达及与血管生成的关系[J].陆军军医大学学报(原第三军医大学学报),2008,30(23):2183-2186. DOI：

　LIU Hui,GUO Jian-wen,LIU Jiang-hui,ZUO Lian-fu.EphA2/EphrinA1 expressions in human gastric carcinoma and their relationship with angiogenesis[J].J Amry Med Univ (J Third Mil Med Univ),2008,30(23):2183-2186. DOI：

摘要

目的探讨EphA2与其配体EphrinA1在胃癌组织中的表达及与肿瘤血管生成的关系。方法利用免疫组织化学法检测82例胃癌手术切除标本中癌组织、癌旁组织及正常胃黏膜中EphA2、EphrinA1的表达，并采用CD34抗体标记微血管内皮细胞，计算微血管密度(MVD)。分析EphA2、EphrinA1的表达与MVD之间的相关性及其与胃癌临床病理特征的关系。结果胃癌组织中EphA2、EphrinA1的表达及MVD显著高于癌旁组织及正常胃黏膜(P0.01)；EphA2、EphrinA1表达水平及MVD值与胃癌的分化程度、浸润深度及淋巴结转移有关(P0.05)，MVD值还与肿瘤直径有关(P0.05)；Spearman等级相关分析表明，EphA2、EphrinA1表达分别与MVD呈显著正相关(r=0.485

P0.01;r= 0.512

P0.01)。结论 EphA2及其配体EphrinA1在胃癌组织中特异性高表达，可能参与肿瘤血管的生成，在胃癌的发病及恶性进展中发挥重要作用。

Abstract

Objective To investigate the expressions of EphA2 and its ligand EphrinA1 and their relationship with angiogenesis in gastric carcinoma. Methods Expressions of EphA2

EphrinA1 and CD34-stained microvessel density (MVD) were detected by immunohistochemical assay in gastric carcinoma tissues

adjacent tissues (1.5 to 2 cm from the mass) and normal gastric mucosa (5 to 10 cm from the mass) from 82 cases. The correlations among EphA2 and EphrinA1 expressions

MVD and clinic pathological features were analyzed. Results EphA2

EphrinA1 expressions and MVD in gastric carcinomas tissues were significantly higher than those in adjacent tissues and normal gastric tissues (P0.01). They were related to histological differentiation

depth of invasion and lymphatic metastasis (P0.05)

while MVD had relationship with diameter of tumor (P0.05). A significant positive correlation between EphA2 or EphrinA1 expression and MVD was observed by the Spearman rank correlation test (r=0.485

P0.01

r=0.512

P0.01). Conclusion EphA2 and its ligand EphrinA1 are specifically over-expressed in gastric cancer and may be involved in the angiogenesis and play an important role in the initiation and progression in gastric carcinoma.

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