Clinical value of  <sup>1</sup>H-magnetic resonance spectroscopy on temporal lobe epilepsy

杨华; 杨柳; 付刘霞; 王文献; 刘丽媛; 杨春艳; 陈林; 安宁

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Clinical value of ¹H-magnetic resonance spectroscopy on temporal lobe epilepsy

更新时间：2026-01-09

- Clinical value of ¹H-magnetic resonance spectroscopy on temporal lobe epilepsy
- Journal of Army Medical University Vol. 30, Issue 20, Pages: 1883-1885(2008)
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  CLC： R749.17;R816.1
- Published：2008
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杨华,杨柳,付刘霞,王文献,刘丽媛,杨春艳,陈林,安宁.磁共振波谱分析在颞叶癫痫的临床应用价值[J].陆军军医大学学报(原第三军医大学学报),2008,30(20):1883-1885.

　YANG Hua,YANG Liu,FU Liu-xia,WANG Wen-xian,LIU Li-yuan,YANG Chun-yan,CHEN Lin,AN Ning.Clinical value of 1H-magnetic resonance spectroscopy on temporal lobe epilepsy[J].J Amry Med Univ (J Third Mil Med Univ),2008,30(20):1883-1885.
杨华,杨柳,付刘霞,王文献,刘丽媛,杨春艳,陈林,安宁.磁共振波谱分析在颞叶癫痫的临床应用价值[J].陆军军医大学学报(原第三军医大学学报),2008,30(20):1883-1885. DOI：

　YANG Hua,YANG Liu,FU Liu-xia,WANG Wen-xian,LIU Li-yuan,YANG Chun-yan,CHEN Lin,AN Ning.Clinical value of 1H-magnetic resonance spectroscopy on temporal lobe epilepsy[J].J Amry Med Univ (J Third Mil Med Univ),2008,30(20):1883-1885. DOI：

摘要

目的评价氢质子磁共振波谱（

HMRS）分析在颞叶癫痫(TLE)病灶术前评定中的价值。方法对45例手术证实为单侧TLE患者的单体素

HMRS数据进行回顾性分析

并以日常检查中随机的14例健康志愿者为对照

计算代谢产物氮-乙酰天门冬氨酸(NAA)、肌酸(Cr)、胆碱复合物(Cho)、NAA/Cr、NAA/Cho、NAA/(Cr＋Cho)的值，比较患者病变组与对侧组、病变组与对照组之间有否差异。结果患者病变组中NAA为(52.31±12.78)ppm

Cr为(40.36±8.06)ppm

Cho为(42.78±10.43)ppm

NAA/Cr为(1.29±0.15)

NAA/Cho为(1.24±0.14)

NAA/(Cr＋Cho)为(0.63±0.05)

对侧组分别为(58.04±13.25)ppm、(40.49±10.02)ppm、(42.42±10.68)ppm、(1.45±0.16)、(1.39±0.13)、(0.70±0.05);对照组分别为(59.86±11.28)ppm、(39.00±7.10)ppm、(40.43±6.61)ppm、(1.55±0.19)、(1.49±0.12)、(0.76±0.06);病变组NAA、NAA/Cr、NAA/Cho、NAA/(Cr＋Cho)较对侧组及对照组明显降低(P0.05）;Cr值和Cho值差异不明显(P0.05)

以NAA/(Cr＋Cho)比值为参考值最可靠（CV在7.04％～7.93％）。NAA/(Cr＋Cho)值取0.65

病变侧与对侧间差值取0.07为标准，对病变定侧诊断的准确率为86.67％

特异性为100％。结论

HMRS分析能够无创地定量反映颞叶生化代谢异常，是TLE患者术前评价的一种有用的辅助检查方法。

Abstract

Objective To evaluate the value of preoperative lateralized

H-magnetic resonance spectroscopy (

HMRS) on temporal lobe epilepsy (TLE). Methods

HMRS of 45 patients with unilateral TLE confirmed surgically and pathologically were retrospectively analyzed

and 10 patients without systemic disease and neurological symptoms served as control. The N-Acetyl L-Aspartic acid (NAA)

Creatine (Cr)

Choline (Cho)

NAA/Cr

NAA/Cho

NAA/(Cr＋Cho) were calculated respectively and compared among the lesion group

the contralateral group and control group. Results NAA

Cho

NAA/Cr

NAA/Cho

NAA/(Cr＋Cho) were

respectively

(52.31±12.78) ppm

(40.36±8.06) ppm

(42.78±10.43) ppm

(1.29±0.15)

(1.24±0.14) and (0.63±0.05) for the lesion group

and (58.04±13.25) ppm

(40.49±10.02) ppm

(42.42±10.68) ppm

(1.45±0.16)

(1.39±0.13)

(0.70±0.05) for contralateral group

and (59.86±11.28) ppm

(39.00±7.10) ppm

(40.43±6.61) ppm

(1.55±0.19)

(1.49±0.12)

(0.76±0.06) for control group. There was significant difference in NAA

NAA/Cr

NAA/Cho

NAA/(Cr＋Cho) between hemispheres with and without lesions (P0.05). The coefficient of variation of NAA/(Cr＋Cho) ranged from 7.04% to 7.93%

and the diagnostic accuracy rate and specificity was 86.67% and 100% respectively when NAA/(Cr＋Cho) ratio was 0.65 and the margin was 0.07. Conclusion

HMRS can quantify biochemical metabolic disorders of temporal lobe and is a complementary modality for evaluating TLE.

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Clinical value of 1H-magnetic resonance spectroscopy on temporal lobe epilepsy

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摘要

Abstract

关键词

Keywords

references

Clinical value of ¹H-magnetic resonance spectroscopy on temporal lobe epilepsy