Anti-tumor efficacy of Angelicae Sinensis decoction for supplementing blood combined with cyclophosphamide

陈鹊汀; 刘智勤; 朱惠学; 徐妍; 王海波; 胡庚坤; 李勇; 蒋玉凤; 黄启福

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Anti-tumor efficacy of Angelicae Sinensis decoction for supplementing blood combined with cyclophosphamide

更新时间：2026-01-09

- Anti-tumor efficacy of Angelicae Sinensis decoction for supplementing blood combined with cyclophosphamide
- Journal of Army Medical University Vol. 30, Issue 16, Pages: 1568-1571(2008)
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  CLC： R289.5;R73-361;R979.1
- Published：2008
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陈鹊汀,刘智勤,朱惠学,徐妍,王海波,胡庚坤,李勇,蒋玉凤,黄启福.当归补血汤联合环磷酰胺抗肿瘤实验研究[J].陆军军医大学学报(原第三军医大学学报),2008,30(16):1568-1571.

　CHEN Que-ting,LIU Zhi-qin,ZHU Hui-xue,XU Yan,WANG Hai-bo,HU Geng-kun,LI Yong,JIANG Yu-feng,HUANG Qi-fu.Anti-tumor efficacy of Angelicae Sinensis decoction for supplementing blood combined with cyclophosphamide[J].J Amry Med Univ (J Third Mil Med Univ),2008,30(16):1568-1571.
陈鹊汀,刘智勤,朱惠学,徐妍,王海波,胡庚坤,李勇,蒋玉凤,黄启福.当归补血汤联合环磷酰胺抗肿瘤实验研究[J].陆军军医大学学报(原第三军医大学学报),2008,30(16):1568-1571. DOI：

　CHEN Que-ting,LIU Zhi-qin,ZHU Hui-xue,XU Yan,WANG Hai-bo,HU Geng-kun,LI Yong,JIANG Yu-feng,HUANG Qi-fu.Anti-tumor efficacy of Angelicae Sinensis decoction for supplementing blood combined with cyclophosphamide[J].J Amry Med Univ (J Third Mil Med Univ),2008,30(16):1568-1571. DOI：

摘要

目的探讨当归补血汤对化疗药物环磷酰胺（cyclophosphamide，CTX）抗S180小鼠的增效减毒作用。方法将接种S180瘤细胞的小鼠分为荷瘤对照组、CTX组、当归补血汤（高、中、低剂量）+CTX组。给药10 d，进行抑瘤率计算，以及外周血常规、骨髓有核细胞计数、脾脏、胸腺质量、肝肾功能、免疫球蛋白等的检测。结果当归补血汤联合CTX各组肿瘤生长明显低于荷瘤对照组（P0.01），当归补血汤高剂量+CTX组肿瘤生长低于CTX组（P0.05）。与荷瘤对照组相比，CTX组脾脏和胸腺指数、IgG、IgM水平明显降低（P0.05

P0.01）；而当归补血汤高、中剂量+CTX组与CTX组相比，脾脏和胸腺指数、IgG、IgM水平明显升高（P0.05，P0.01）。与荷瘤对照组相比，CTX组ALT升高，WBC、PLT和骨髓有核细胞计数降低；而当归补血汤高、中剂量+CTX组相对于CTX组，ALT降低，WBC、PLT和骨髓有核细胞计数升高（P0.05，P0.01）。结论当归补血汤对化疗药物CTX抗S180小鼠具有增效减毒的作用。

Abstract

Objective To observe the effect of Angelicae Sinensis decoction for supplementing blood (AS) in enhancing the efficacy of chemotherapy and against its side-effect in mice loaded with S180 murine sarcoma cells. Methods The mice inoculated with S180 murine sarcoma cells were divided into 5 groups: S180 control group

0.02 g·kg

-1

·d

-1

cyclophosphamide (CTX) group

AS (24

6 g·kg

-1

·d

-1

as high

moderate and low dose)+CTX groups. After 10-day treatment

the tumor inhibition rate

the counting of peripheral blood cells and bone marr

ow karyocytes

the weight of spleen and thymus were calculated

and the liver and renal function and immunoglobulin (Ig) were evaluated. Results The tumor inhibition rate was higher in each AS+CTX group than that in the S180 control group (P0.01). The tumor inhibition rate of high-dose AS+CTX group was higher than CTX group (P0.05). The indexes of spleen and thymus as well as the levels of IgG and IgM in CTX group were lower than those of S180 control group and high- and moderate-dose AS+CTX groups (P0.05 or P0.01). ALT level was higher and WBC

PLT and BMC were lower in CTX group than those in S180 control group and high- and moderate-dose AS+CTX groups (P0.05 or P0.01). Conclusion AS can enhance the efficacy of chemotherapy and reduce its side-effect in the mice with S180 murine sarcoma cells exposed to CTX.

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