Objective    To evaluate the clinical values of C-12 multiple tumor marker protein chip detection system in diagnosis of tumor

and establish the diagnostic function to evaluate the accuracy rate of diagnosis.     Methods    Totally 5 600 subjects were recruited

including 1 209 physical examiners

660 benign patients and 3 731 patients of malignant tumors. Their clinical data were retrospectively studied and 12 tumor markers (CA199

NSE

CEA

CA242

CA125

CA153

AFP

Fer

F-PSA

PSA

HGH and β-HCG) were detected by protein chip technology

then the diagnostic function was established to compare the accuracy rate made according to the diagnostic result with 12 tumor markers.     Results    ①At least one kind of tumor marker was found positive in 128 subjects out of 1 209 physical examiners

with the positive rate of 10.59% that was significantly lower than that of the two tumor groups. ②The accuracy rate in the physical examiners was 89.66% by C-12 multiple tumor marker protein chip detection system

while 62.77% in tumor patients. The sensitivity by this method was 66.11% and the specificity was 48.68%. ③The accuracy rate in physical examiners was 93.7% by the diagnostic function

while 75.7% in tumor patients.     Conclusion    The combined use of the selected biomarkers in diagnosis has higher sensitivity and specificity

and is of great potential for the early detection of cancer. The diagnostic function can promote the diagnostic accuracy rate of cancers to some extent.