Expression and significance of PAX-5, OCT-2 and BOB.1 in Hodgkin lymphoma

范严严; 章容; 郭乔楠

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Expression and significance of PAX-5, OCT-2 and BOB.1 in Hodgkin lymphoma

更新时间：2026-01-09

- Expression and significance of PAX-5, OCT-2 and BOB.1 in Hodgkin lymphoma
- Journal of Army Medical University Vol. 30, Issue 15, Pages: 1466-1469(2008)
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  CLC： R446.8;R730.21;R733.1
- Published：2008
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范严严,章容,郭乔楠.PAX-5、OCT-2及BOB.1在霍奇金淋巴瘤中的表达及其意义[J].陆军军医大学学报(原第三军医大学学报),2008,30(15):1466-1469.

　FAN Yan-yan,ZHANG Rong,GUO Qiao-nan.Expression and significance of PAX-5, OCT-2 and BOB.1 in Hodgkin lymphoma[J].J Amry Med Univ (J Third Mil Med Univ),2008,30(15):1466-1469.
范严严,章容,郭乔楠.PAX-5、OCT-2及BOB.1在霍奇金淋巴瘤中的表达及其意义[J].陆军军医大学学报(原第三军医大学学报),2008,30(15):1466-1469. DOI：

　FAN Yan-yan,ZHANG Rong,GUO Qiao-nan.Expression and significance of PAX-5, OCT-2 and BOB.1 in Hodgkin lymphoma[J].J Amry Med Univ (J Third Mil Med Univ),2008,30(15):1466-1469. DOI：

摘要

目的探讨PAX-5、OCT-2、BOB.1在霍奇金淋巴瘤中的表达情况及其意义。方法对44例霍奇金淋巴瘤行HE染色和应用免疫组织化学PV-9000法标记CD30、CD15、PAX-5、OCT-2、BOB.1、CD20、CD3，按WHO关于淋巴造血组织肿瘤分类(2001年)进行诊断和组织学分型。结果 44例霍奇金淋巴瘤中，结节性淋巴细胞为主型(NLPHL)3例(6.8%)，经典型霍奇金淋巴瘤(CHL)41例(93.2%)。HRS细胞有36例(81.8%)表达CD30，27例(61.4%)表达CD15，14例(31.8%)表达CD20，43例(97.7%)表达PAX-5，14例(31.8%)表达OCT-2，7例(15.9%)表达BOB.1，其中NLPHL OCT-2、BOB.1均为阳性(100%)，CHL中有30例(73.2%)均不表达OCT-2和BOB.1，7例(17.1%)OCT2(+)、BOB.1(-)，1例(2.4%)OCT-2(-)、BOB.1(+)。所有病例均不表达CD3。结论霍奇金淋巴瘤是一种病因不明，诊断较困难的恶性肿瘤，PAX-5、OCT-2、BOB.1标记与传统的CD30、CD15相结合，有助于霍奇金淋巴瘤的诊断及鉴别诊断。

Abstract

Objective To investigate the expressions and significance of PAX-5

OCT-2 and BOB.1 in Hodgkin lymphoma (HL). Methods Immunohistochemical method was used to detect the expressions of CD30

CD15

PAX-5

OCT-2

BOB.1

CD20 and CD3 in 44 samples of formalin-fixed

paraffin-embedded tissues of HL. The histological classification was carried out according to the WHO classification for tumors of hematopoietic and lymphoid tissues (2001). Results In all 44 cases

3 (6.8%) were nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) and 41 (93.2%) were classical Hodgkin lymphoma (CHL). In Hodgkin and Reed Sternberg cells

CD30 were expressed in 36 samples (81.8%)

CD15 in 27 (61.4%)

CD20 in 14 (31.8%)

PAX-5 in 43 (97.7%)

OCT-2 in 14 (31.8%)

and BOB.1 in 7 (15.9%). All samples of NLPHL expressed OCT-2 and BOB.1

while in the samples of CHL

30 samples (73.2%) expressed both OCT-2 and BOB.1

7 (17.1%) expressed only OCT-2

1 (2.4%) expressed only BOB.1 and all were negative for CD30. Conclusion Hodgkin lymphoma is a rare neoplasm with uncertain cause and difficult to diagnose. The detection of PAX-5

OCT-2

BOB.1 in combination with CD30

CD15 will conduce to the diagnosis and differential diagnosis of Hodgkin lymphoma.

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