Effect of simvastatin on RhoA expression and cardiac remodeling with in acute myocardiac infarction rats

袁侨英; 覃数; 司良毅; 李学军

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Effect of simvastatin on RhoA expression and cardiac remodeling with in acute myocardiac infarction rats

更新时间：2026-01-09

- Effect of simvastatin on RhoA expression and cardiac remodeling with in acute myocardiac infarction rats
- Journal of Army Medical University Vol. 30, Issue 12, Pages: 1170-1172(2008)
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  CLC： R322.11;R542.22;R972.6
- Published：2008
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袁侨英,覃数,司良毅,李学军.辛伐他汀对急性心肌梗死大鼠RhoA表达及心室重塑的影响[J].陆军军医大学学报(原第三军医大学学报),2008,30(12):1170-1172.

　YUAN Qiao-ying,QIN Shu,SI Liang-yi,LI Xue-jun.Effect of simvastatin on RhoA expression and cardiac remodeling with in acute myocardiac infarction rats[J].J Amry Med Univ (J Third Mil Med Univ),2008,30(12):1170-1172.
袁侨英,覃数,司良毅,李学军.辛伐他汀对急性心肌梗死大鼠RhoA表达及心室重塑的影响[J].陆军军医大学学报(原第三军医大学学报),2008,30(12):1170-1172. DOI：

　YUAN Qiao-ying,QIN Shu,SI Liang-yi,LI Xue-jun.Effect of simvastatin on RhoA expression and cardiac remodeling with in acute myocardiac infarction rats[J].J Amry Med Univ (J Third Mil Med Univ),2008,30(12):1170-1172. DOI：

摘要

目的在大鼠心肌梗死模型上，观察辛伐他汀是否下调小G蛋白RhoA mRNA及蛋白质表达，及其与改善大鼠心肌梗死后心室重塑和心脏功能的关系。方法制备心肌梗死模型，予辛伐他汀干预。8周后，测定心脏质量指数、血流动力学指标、心肌RhoA mRNA及蛋白质表达，并与假手术组比较。结果心肌梗死组较假手术组大鼠心脏质量指数升高、血流动力学恶化(P0.01)；心肌RhoA mRNA及蛋白质表达升高(P0.01)。辛伐他汀干预组较心肌梗死组心肌RhoA mRNA及蛋白质表达下降、心脏质量指数及血流动力学指标均改善(P0.01)。结论辛伐他汀改善左室重塑和心功能，这可能与其在基因转录和蛋白质翻译水平抑制RhoA表达等综合作用有关。

Abstract

Objective To investigate the effects of simvastatin on the abatement of the mRNA

protein expression of RhoA and the improvement of the cardiac remodeling and cardiac disfunction after the myocardiac infarction in rats. Methods Rats were divided into 3 groups: the control group

the myocardiac infarction group and Simvastatin intervened group. After 8 weeks

cardiac weight index and hemodynamics were observed

mRNA and protein expression of RhoA in cardiac muscles was measured. Results Compared with the control group

the cardiac weight index and the mRNA and protein expression were increased in rats with myocardiac infarction and the hemodynamics was worsened (P0.01) while compared with the group with simvastatin intervention

the cardiac weight index and the hemodynamics were improved and the mRNA and expression of RhoA was decreased (each P0.01). Conclusion Simvastatin abates the mRNA and protein expression of RhoA

which may be one of the mechnisms in the improvement of the cardiac remodeling and cardiac disfunction after acute myocardiac infarction.

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