Atorvastatin downregulates MMP-2, MMP-9  in brain of rats with focal cerebral ischemia-reperfusion

蔡志友; 晏勇; 余昌胤; 张骏; 黄良国; 胡永涛; 周妮; 王凤英

您当前的位置：

首页 >

文章列表页 >

Atorvastatin downregulates MMP-2, MMP-9 in brain of rats with focal cerebral ischemia-reperfusion

更新时间：2026-01-09

- Atorvastatin downregulates MMP-2, MMP-9 in brain of rats with focal cerebral ischemia-reperfusion
- Journal of Army Medical University Vol. 30, Issue 19, Pages: 1828-1831(2008)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：
  CLC： R741.02;R743.21;R972.6
- Published：2008
- 稿件说明：
移动端阅览
蔡志友,晏勇,余昌胤,张骏,黄良国,胡永涛,周妮,王凤英.阿托伐他汀抑制脑缺血再灌注大鼠脑组织MMP-2、MMP-9表达[J].陆军军医大学学报(原第三军医大学学报),2008,30(19):1828-1831.

　CAI Zhi-you,YAN Yong,YU Chang-yin,ZHANG Jun,HUANG Liang-guo,HU Yong-tao,ZHOU Ni,WANG Feng-ying.Atorvastatin downregulates MMP-2, MMP-9 in brain of rats with focal cerebral ischemia-reperfusion[J].J Amry Med Univ (J Third Mil Med Univ),2008,30(19):1828-1831.
蔡志友,晏勇,余昌胤,张骏,黄良国,胡永涛,周妮,王凤英.阿托伐他汀抑制脑缺血再灌注大鼠脑组织MMP-2、MMP-9表达[J].陆军军医大学学报(原第三军医大学学报),2008,30(19):1828-1831. DOI：

　CAI Zhi-you,YAN Yong,YU Chang-yin,ZHANG Jun,HUANG Liang-guo,HU Yong-tao,ZHOU Ni,WANG Feng-ying.Atorvastatin downregulates MMP-2, MMP-9 in brain of rats with focal cerebral ischemia-reperfusion[J].J Amry Med Univ (J Third Mil Med Univ),2008,30(19):1828-1831. DOI：

摘要

目的观察阿托伐他汀对大鼠脑缺血再灌注脑组织MMP-2、MMP-9表达的影响，探讨阿托伐他汀对脑缺血再灌注脑保护作用机制。方法将Wistar大鼠随机分组：正常组（N组）、缺血再灌注组（IR组）、假手术组（NS组）、阿托伐他汀对照组（At组）、阿托伐他汀治疗组（AtT组）、阿托伐他汀预处理组（AtP组）。采用免疫组织化学法检测大鼠脑组织MMP-2、MMP-9表达，用图像分析仪测定光密度值，电镜下分析面密度。结果 AtT、AtP组脑组织MMP-2、MMP-9表达较IR组明显降低（P0.05），较NS、N、At组明显增高（P0.01）；梗死灶体积AtT、AtP组较IR组明显降低（P0.05），较NS、N、At组明显增高（P0.01）。结论阿托伐他汀能抑制大鼠脑缺血再灌注后能脑组织MMP-2、MMP-9表达，发挥脑保护作用。

Abstract

Objective To study the neuroprotective mechanism of atorvastatin against the injury induced by cerebral ischemia-reperfusion. Methods Wistar rats were randomly divided into: normal group (N)

ischemia-reperfusion group (IR)

sham-operation group (NS)

atorvastatin group (At)

atorvastatin treatment group (AtT) and atorvastatin preconditioning group (AtP). The rat model of focal cerebral ischemia-reperfusion was established by inserting a piece of nylon thread into the left internal carotid artery. Ischemia of 30 min and reperfusion of 30 min were carried out alternately for 12 h or 24 h respectively. Their expressions of MMP-2 and MMP-9 in brain tissues were measured by immunohistochemical methods and their optic density value was measured by imaging analysis system. The positive cells for MMP-2 and MMP-9 expressions were counted under optic microscope. Results The expressions of MMP-2 and MMP-9 in AtP and AtT groups were lower than those in IR group (P0.05)

significantly higher than those in NS

At groups (P0.01); Infarct volume was smaller than that of in IR group (P0.05)

significantly higher than that in NS

At groups (P0.01). Conclusion Atorvastatin can downregulate MMP-2 and MMP-9 expressions and restrain infarct volume during focal cerebral ischemia-reperfusion. The treatment with atorvastatin can protect neural function by maintaining the structural integrality of blood brain barrier.

关键词

Keywords

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Luteolin attenuates oxidative stress in mice with cerebral ischemia-reperfusion by inhibiting Drp1 activation and promoting autophagy flux

Effect of high-dose statins in patients with ST-segment elevation myocardial infarction undergoing percutaneous coronary intervention: a meta-analysis and systematic review

Effect of preoperative single intensive statin on postoperative serum inflammation factors, platelet activity and major adverse cardiac events in stable angina patients after percutaneous coronary intervention

Atorvastatin suppresses nuclear translocation of NF-κB p65 in LPS-induced abdominal macrophage of ApoE^-/- mouse

Atorvastatin inhibits CTGF and Cx43 expressions in primarily cultured rat atrial myocytes

Related Author

Yundong ZHANG

Chenyang DUAN

Hang JIANG

Bo CHEN

Yujie LAI

Long WANG

Xue ZENG

Shengyan WEN

Related Institution

Center of Neuropathies, the Third Affiliated Hospital of Chongqing Medical University

Department of Neurosurgery, First Affiliated Hospital, Army Medical University (Third Military Medical University)

State Key Laboratory of Trauma, Burns and Combined Injury, Department of War Wound Shock and Blood Transfusion, Institute of Surgery Research, Army Medical University (Third Military Medical University)

Department of Cardiology, the Second Affiliated Hospital of Chongqing Medical University

⁰