Electroacupuncture treats rat non-alcoholic fatty liver by blocking insulin resistance and peroxidation

曾志华; 曾明慧; 冯雯琪; 卓廉士

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Electroacupuncture treats rat non-alcoholic fatty liver by blocking insulin resistance and peroxidation

更新时间：2026-01-09

- Electroacupuncture treats rat non-alcoholic fatty liver by blocking insulin resistance and peroxidation
- Journal of Army Medical University Vol. 30, Issue 11, Pages: 1055-1057(2008)
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  CLC： R-332;R246;R575.505
- Published：2008
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曾志华,曾明慧,冯雯琪,卓廉士.电针阻断胰岛素抵抗及过氧化反应治疗非酒精性脂肪肝的实验研究[J].陆军军医大学学报(原第三军医大学学报),2008,30(11):1055-1057.

　ZENG Zhi-hua,ZENG Ming-hui,FENG Wen-qi,ZHUO Lian-shi.Electroacupuncture treats rat non-alcoholic fatty liver by blocking insulin resistance and peroxidation[J].J Amry Med Univ (J Third Mil Med Univ),2008,30(11):1055-1057.
曾志华,曾明慧,冯雯琪,卓廉士.电针阻断胰岛素抵抗及过氧化反应治疗非酒精性脂肪肝的实验研究[J].陆军军医大学学报(原第三军医大学学报),2008,30(11):1055-1057. DOI：

　ZENG Zhi-hua,ZENG Ming-hui,FENG Wen-qi,ZHUO Lian-shi.Electroacupuncture treats rat non-alcoholic fatty liver by blocking insulin resistance and peroxidation[J].J Amry Med Univ (J Third Mil Med Univ),2008,30(11):1055-1057. DOI：

摘要

目的探讨电针阻断胰岛素抵抗及过氧化反应治疗非酒精性脂肪肝(non-alcoholic fatty liver disease

NAFLD)的机制。方法 SD大鼠33只按随机抽签法分组：正常对照组(11只)，造模组(22只)。正常组以普通饲料喂养，造模组以高脂饲料喂养，8周后处死3只（正常对照组1只，造模组2只），验证造模成功后将造模组分为NAFLD模型组(10只)和电针治疗组(10只)，后者施以电针治疗。12周末处死所有大鼠检测血糖（FBG）、血清胰岛素（FINS）、血清游离脂肪酸（FFA）、肝内丙二醛（MDA）、超氧化物歧化酶（SOD）、甘油三酯(TG)、总胆固醇(TC)、谷胱甘肽（GSH）含量变化及肝组织病理学。结果与模型组比较，电针组FBG、FINS、FFA降低（P0.05）；肝内MDA、TG、TC显著下降(P0.01)；SOD、GSH活性升高(P0.01)，肝组织脂肪变性和炎性损伤得以改善。结论电针通过阻止胰岛素抵抗和过氧化反应之间的恶性循环治疗NAFLD。

Abstract

Objective To investigate the mechanism of electroacupuncture in the treatment of non-alcoholic fatty liver disease (NAFLD) . Methods Thirty-three male SD rats were randomized into 2 groups: normal control group (n=11

fed with normal food) and experimental rats (n=23

fed with high-fat food). Eight weeks later

3 rats were randomly selected from the 2 groups respectively and killed to undergo pathological examination of the liver. When the establishment of experimental rats was confirmed

the remaining 20 experimental rats were divided into 2 equal subgroups: NAFLD group (fed continuously with high-fat food) and electroacupuncture treatment group (fed continuously with high-fat food and received the treatment 15 min per day

once a day for 4 weeks). Then all rats were killed to detect the serum levels of fasting blood glucose (FBG)

fasting insulin (FINS) and free fatty acids (FFA)

liver contents of malondialdehyde (MDA)

glycerin tripalmitate (TG) and total cholesterol (TC)

and the activities of liver superoxide dismutase (SOD) and glutathione (GSH). Liver pathological changes was examined. Results Compared with NAFLD group

electroacupuncture reduced the serum levels of FBG

FINS and FFA (P0.05)

the liver contents of MDA

TG and TC (P0.01)

and increased the activities of SOD and GSH (P0.01). It also attenuated the liver fatty degeneration and inflammatory injury. Conclusion Electroacupuncture can treat NAFLD by blocking the vicious circle of insulin resistance and perooxidation.

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