Effect of cerebral ischemia on the cognitive function of Alzheimer’s disease model of rats

李静; 周华东; 王延江; 张猛; 方传勤

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Effect of cerebral ischemia on the cognitive function of Alzheimer’s disease model of rats

更新时间：2026-01-09

- Effect of cerebral ischemia on the cognitive function of Alzheimer’s disease model of rats
- Journal of Army Medical University Vol. 30, Issue 13, Pages: 1264-1267(2008)
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  CLC： R338.6;R743.31;R749.16
- Published：2008
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李静,周华东,王延江,张猛,方传勤.脑缺血对阿尔茨海默病大鼠认知功能的影响[J].陆军军医大学学报(原第三军医大学学报),2008,30(13):1264-1267.

　LI Jing,ZHOU Hua-dong,WANG Yan-jiang,ZHANG Meng,FANG Chuan-qin.Effect of cerebral ischemia on the cognitive function of Alzheimer’s disease model of rats[J].J Amry Med Univ (J Third Mil Med Univ),2008,30(13):1264-1267.
李静,周华东,王延江,张猛,方传勤.脑缺血对阿尔茨海默病大鼠认知功能的影响[J].陆军军医大学学报(原第三军医大学学报),2008,30(13):1264-1267. DOI：

　LI Jing,ZHOU Hua-dong,WANG Yan-jiang,ZHANG Meng,FANG Chuan-qin.Effect of cerebral ischemia on the cognitive function of Alzheimer’s disease model of rats[J].J Amry Med Univ (J Third Mil Med Univ),2008,30(13):1264-1267. DOI：

摘要

目的探讨脑缺血对阿尔茨海默病(Alzheimer’s disease

AD)模型大鼠认知功能的影响。方法大鼠分为脑缺血组、AD组、AD+脑缺血组和对照组。大鼠右侧纹状体注射内皮素1（endothelin-1

ET-1）建立脑缺血模型；右侧海马齿状回注射凝聚态Aβ

1-40

建立AD模型；二者结合建立AD+脑缺血模型。穿梭箱和水迷宫实验检测各组大鼠的学习能力。结果穿梭箱实验中AD+脑缺血组的主动、被动回避反应率最低，AD组次之，对照组最高（P0.01

P0.05）。水迷宫定位航行实验中，AD＋脑缺血组的平均逃避潜伏期最长，AD组次之，对照组最短（P0.01）；空间搜索实验中AD＋脑缺血组初次找到平台的时间最长，AD组次之，对照组最短（P0.01）；AD＋脑缺血组跨越平台的次数最少，AD组次之，对照组最多（P0.01）。结论脑缺血后AD大鼠的认知功能下降更明显，脑缺血加剧了AD认知功能损害的进展。

Abstract

Objective To investigate the effect of cerebral ischemia on the cognitive function of rats with Alzheimer’s disease(AD) and the role of cerebral ischemia in progression of cognitive damage of AD. Methods The male SD rats were divided randomly into 4 groups: the control group

the ischemia group

the AD group and the ischemia plus AD group. endothelin-1(ET-1) injections was given to ischemia group into the right striatum; β

1-40

injections to AD group in the right dentate gyrus

and both ET-1 and Aβ

1-40

injections to the ischemia plus group. The cognitive functions of the 4 groups of rats was detected by Morris wat

er maze and shuttle box. Results The AAR％ and PAR％ of AD plus cerebral ischemia group were the lowest in the four groups in shuttle box experiment (P0.01

P0.05)

followed by the AD group and the control group. In navigation test of Morris water maze

the average escape latency of AD plus cerebral ischemia group was the longest in the four groups (P0.01). In spatial probe test of Morris water maze

the initial time taken to reach the hidden prior platform of AD plus cerebral ischemia group was the longest （P0.01) and its frequency passing through the prior platform was the lowest(P0.01)

followed by the AD group and the control group. Conclusions The cognitive function of rats in the AD group decreased significantly after cerebral ischemia

which aggravated the cognitive damage of AD.

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