Formulation and preparation of glycyrrhizic acid solid lipid nanoparticles

侯君; 周世文

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Formulation and preparation of glycyrrhizic acid solid lipid nanoparticles

更新时间：2026-01-09

- Formulation and preparation of glycyrrhizic acid solid lipid nanoparticles
- Journal of Army Medical University Vol. 30, Issue 11, Pages: 1043-1045(2008)
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  CLC： R282.71;R943;R944.9
- Published：2008
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侯君,周世文.甘草酸固体脂质纳米粒的处方及制备工艺[J].陆军军医大学学报(原第三军医大学学报),2008,30(11):1043-1045.

　HOU Jun,ZHOU Shi-wen.Formulation and preparation of glycyrrhizic acid solid lipid nanoparticles[J].J Amry Med Univ (J Third Mil Med Univ),2008,30(11):1043-1045.
侯君,周世文.甘草酸固体脂质纳米粒的处方及制备工艺[J].陆军军医大学学报(原第三军医大学学报),2008,30(11):1043-1045. DOI：

　HOU Jun,ZHOU Shi-wen.Formulation and preparation of glycyrrhizic acid solid lipid nanoparticles[J].J Amry Med Univ (J Third Mil Med Univ),2008,30(11):1043-1045. DOI：

摘要

目的制备甘草酸固体脂质纳米粒（GL-SLN）。方法用旋转蒸发薄膜超声法制备GL-SLN，在单因素考察的基础上，通过正交设计优选该纳米粒的处方及制备工艺，并对优化条件下制备的GL-SLN进行质量评价。结果制备的GL-SLN大小较均匀，平均粒径为75.8 nm，zeta电位-19.7 mV，载药量8.27%

包封率91.76%。结论薄膜超声分散法优化工艺制备得到的GL-SLN包封率较高，稳定性好，方法可靠。

Abstract

Objective To prepare the glycyrrhizic acid solid lipid nanoparticles (GL-SLN). Methods GL-SLN was prepared by conventional rotary-evaporated film-ultrasonication method. Based on the single-factor experiment

GL-SLN was prepared using orthogonal design for optimization of formulation and technology. The obtained GL-SLN was also evaluated. Results GL-SLN had even and regular appearance and the average diameter was 75.8 nm. Zeta potential was -19.7 mV. The drug loading was 8.27% and the entrapment ratio was 91.76%. Conclusion The entrapment ratio of GL-SLN and the stability of GL-SLN prepared by conventional rotary-evaporated film-ultrasonication method are high and good.

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