Expression of p16<sup>INK4a</sup> protein and its relationship with HPV in cervical cancer and precancerous lesions

李军果; 李力; 郭建新; 高奉浔; 赵雯

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Expression of p16^INK4a protein and its relationship with HPV in cervical cancer and precancerous lesions

更新时间：2026-01-09

- Expression of p16^INK4a protein and its relationship with HPV in cervical cancer and precancerous lesions
- Journal of Army Medical University Vol. 30, Issue 10, Pages: 928-931(2008)
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  CLC： R373;R730.23;R737.33
- Published：2008
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李军果,李力,郭建新,高奉浔,赵雯.p16INK4a蛋白在宫颈疾病中的表达特点及其与HPV感染的关系[J].陆军军医大学学报(原第三军医大学学报),2008,30(10):928-931.

　LI Jun-guo,LI Li,GUO Jian-xin,GAO Feng-xun,ZHAO Wen.Expression of p16INK4a protein and its relationship with HPV in cervical cancer and precancerous lesions[J].J Amry Med Univ (J Third Mil Med Univ),2008,30(10):928-931.
李军果,李力,郭建新,高奉浔,赵雯.p16INK4a蛋白在宫颈疾病中的表达特点及其与HPV感染的关系[J].陆军军医大学学报(原第三军医大学学报),2008,30(10):928-931. DOI：

　LI Jun-guo,LI Li,GUO Jian-xin,GAO Feng-xun,ZHAO Wen.Expression of p16INK4a protein and its relationship with HPV in cervical cancer and precancerous lesions[J].J Amry Med Univ (J Third Mil Med Univ),2008,30(10):928-931. DOI：

摘要

目的研究伴有高危型人乳头瘤病毒（highrisk human papillomavirus， hr-HPV）感染及无hr-HPV感染的宫颈癌（cervical cancer， CC）、宫颈上皮内瘤变（cervical intraepithelial neoplasia， CIN）及宫颈炎中p16

INK4a

蛋白表达水平的变化及意义，探讨宫颈癌及癌前病变中p16

INK4a

蛋白表达与HPV感染的相关性。方法应用免疫组化方法检测126例宫颈疾病（CC 40例，CIN 67例和宫颈炎19例）组织中p16

INK4a

蛋白的表达，其中，hr-HPV（+）宫颈疾病89例（CC 32例，CIN 48例和宫颈炎9例），hr-HPV(-）宫颈疾病37例（CC 8例，CIN 19例和宫颈炎10例），进行半定量分析及统计学检验。 结果 40例CC中，p16

INK4a

全部阳性表达；48例hrHPV（+）和19例hrHPV(-）CIN中，p16

INK4a

阳性表达分别为39例和12例；9例hrHPV（+）和10例hrHPV(-）宫颈炎组织中，p16

INK4a

阳性表达均为4例。hr-HPV（+）或hr-HPV(-）宫颈炎、宫颈上皮内瘤变和宫颈癌组织中p16

INK4a

蛋白表达水平均依次升高。CC和CIN中p16

INK4a

蛋白表达与hr-HPV感染相互间无显著相关性（P0.05）。结论细胞周期抑制蛋白p16

INK4a

在CC及癌前病变中过表达，且与hr-HPV感染无关，提示p16

INK4a

蛋白在宫颈癌的发生、发展中所起的作用和作用机制可能与其在其他恶性肿瘤中不同。检测p16

INK4a

蛋白表达有助于CC的早期诊断。

Abstract

Objective To study whether p16

INK4a

protein expressions in cervical cancer (CC)

cervical intraepithelial neoplasia (CIN) and cervicitis are associated with highrisk human papillomav

irus (hr-HPV) infection. Methods The expressions of p16

INK4a

protein were detected in 126 samples of cervical lesions (40 CC

67 CIN

19 cervicitis) by immunohistochemical staining

among which 89 cervical lesions were hr-HPV(+) (32 CC

48 CIN

9 cervicitis) and 37 hr-HPV(-) (8 CC

19 CIN

10 cervicitis). Results p16

INK4a

protein was positive in all of CC samples. The positive expression of p16

INK4a

was in 39 hr-HPV(+) samples and 12 hr-HPV(-) CIN samples

with no significant difference between each other. The positive expression of p16

INK4a

was in 4 hr-HPV(+) and 4 hr-HPV(-) cervicitis samples. The p16

INK4a

expression increased in the samples of cervicitis

CIN to CC in turn

and the significant difference was observed among them regardless of hr-HPV infection. Pearson correlation analysis revealed no correlation between hr-HPV infection and p16

INK4a

protein expressions in CC and CIN (P0.05). Conclusion Overexpression of INK4a gene indicates the potential of CC development. Moreover

there is no correlation between the overexpression of p16

INK4a

protein and hr-HPV state in cervical lesions. Therefore

it is likely that p16

INK4a

protein expression is not induced by the same carcinogenic mechanisms of CC and other malignant tumors. Overexpression of INK4a gene helps in the diagnosis of cervical cancer.

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Expression of p16INK4a protein and its relationship with HPV in cervical cancer and precancerous lesions

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Expression of p16^INK4a protein and its relationship with HPV in cervical cancer and precancerous lesions