VEGF enhances serum levels of HGF and IL-6 in rats following 50 percent partial liver transplantation

董晓灵; 王曙光; 张玉君; 江燕

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VEGF enhances serum levels of HGF and IL-6 in rats following 50 percent partial liver transplantation

更新时间：2026-01-09

- VEGF enhances serum levels of HGF and IL-6 in rats following 50 percent partial liver transplantation
- Journal of Army Medical University Vol. 30, Issue 11, Pages: 1037-1039(2008)
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  CLC： R392.7;R446.11;R657.3
- Published：2008
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董晓灵,王曙光,张玉君,江燕.VEGF对大鼠50％肝脏移植术后血清HGF、IL-6浓度的影响[J].陆军军医大学学报(原第三军医大学学报),2008,30(11):1037-1039.

　DONG Xiao-ling,WANG Shu-guang,ZHANG Yu-jun,JIANG Yan.VEGF enhances serum levels of HGF and IL-6 in rats following 50 percent partial liver transplantation[J].J Amry Med Univ (J Third Mil Med Univ),2008,30(11):1037-1039.
董晓灵,王曙光,张玉君,江燕.VEGF对大鼠50％肝脏移植术后血清HGF、IL-6浓度的影响[J].陆军军医大学学报(原第三军医大学学报),2008,30(11):1037-1039. DOI：

　DONG Xiao-ling,WANG Shu-guang,ZHANG Yu-jun,JIANG Yan.VEGF enhances serum levels of HGF and IL-6 in rats following 50 percent partial liver transplantation[J].J Amry Med Univ (J Third Mil Med Univ),2008,30(11):1037-1039. DOI：

摘要

目的探讨血管内皮生长因子（vascular endothelial growth factor，VEGF）对大鼠部分肝移植术后血清肝细胞生长因子（hepatocyte growth factor，HGF）、白细胞介素-6（interleukin-6，IL-6）浓度的影响。方法建立大鼠50%部分肝移植模型。实验动物分3组：VEGF治疗组、antiVEGF组、对照组。分别于术后注射鼠重组VEGF、 anti-VEGF、生理盐水。在术后不同时相点(0、12、24、72、168 h)测血清中HGF、IL-6 含量及肝脏生化指标。结果 VEGF组血清HGF、IL-6水平较对照组明显增高，antiVEGF组较对照组明显降低，有显著差异。anti-VEGF 组天冬氨酸转氨酶(aspartate aminotransferase，AST)、丙氨酸转氨酶（alanine aminotransferase，ALT）较VEGF组及对照组明显升高，有显著差异。结论 VEGF治疗能明显促进大鼠部分肝脏移植术HGF、IL-6的释放。

Abstract

Objective To determine the effects of exogenous VEGF on the serum levels of HGF and IL-6 in rats following partial liver transplantation. Methods Totally 180 SD rats were subjected to 50 percent partial liver transplantation

then each 60 rats were treated either with VEGF

anti-VEGF or normal saline. HGF

IL-6 and hepatic biochemical markers were assessed at 0

168 h after operation. Results In the VEGF group

the serum levels of HGF and IL-6 were significantly increased as compared with those of anti-VEGF group or control group. Blockage of endogenous VEGF led to a marked increase of ALT and AST. Conclusion VEGF can markedly increase the secretion of HGF and IL-6

which may be related to its enhancing liver regeneration and improving liver function.

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