Effects of telmisartan on cognition and GHSR expression in frontal cortex of diabetic rats

张海娜; 高原; 吴绮楠; 肖谦

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Effects of telmisartan on cognition and GHSR expression in frontal cortex of diabetic rats

更新时间：2026-01-09

- Effects of telmisartan on cognition and GHSR expression in frontal cortex of diabetic rats
- Journal of Army Medical University Vol. 30, Issue 14, Pages: 1342-1345(2008)
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  CLC： R587.1;R749.24;R972.4
- Published：2008
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张海娜,高原,吴绮楠,肖谦.替米沙坦对糖尿病大鼠认知功能及大脑皮质Ghrelin受体表达的影响[J].陆军军医大学学报(原第三军医大学学报),2008,30(14):1342-1345.

　ZHANG Hai-na,GAO Yuan,WU Qi-nan,XIAO Qian.Effects of telmisartan on cognition and GHSR expression in frontal cortex of diabetic rats[J].J Amry Med Univ (J Third Mil Med Univ),2008,30(14):1342-1345.
张海娜,高原,吴绮楠,肖谦.替米沙坦对糖尿病大鼠认知功能及大脑皮质Ghrelin受体表达的影响[J].陆军军医大学学报(原第三军医大学学报),2008,30(14):1342-1345. DOI：

　ZHANG Hai-na,GAO Yuan,WU Qi-nan,XIAO Qian.Effects of telmisartan on cognition and GHSR expression in frontal cortex of diabetic rats[J].J Amry Med Univ (J Third Mil Med Univ),2008,30(14):1342-1345. DOI：

摘要

目的观察替米沙坦对糖尿病大鼠认知功能和大脑皮质Ghrelin受体GHSR的表达影响。方法将40只大鼠分为正常对照组、糖尿病组、替米沙坦组。建立STZ糖尿病大鼠模型，替米沙坦干预12周，Morris水迷宫测试其认知能力。RT-PCR检测大脑皮质GHSR mRNA水平表达变化，免疫组化观察大鼠大脑皮质GHSR蛋白的表达。结果替米沙坦组与糖尿病组比较，Morris水迷宫测试中潜伏期明显缩短（P0.05），中心区停留时间百分比和通过原平台位置次数增加(P0.05)，免疫组化显示GHSR蛋白表达增加(P0.05)，RT-PCR显示GHSR在mRNA水平表达增加(P0.05)。结论糖尿病引起大鼠认知功能下降和GHSR表达下降，GHSR下降可能与认知障碍有关。早期替米沙坦治疗可使糖尿病大鼠认知功能和海马GHSR表达接近正常。

Abstract

Objective To observe the effects of telmisartan on cogtive function and the expression of Ghrelin receptors

growth hormone secretagogues receptor(GHSR) in diabetic rats. Methods Forty rats were randomly divided into 3 groups: control group

diabetic model group

and telmisartan treatment group. Streptozotocin-induced diabetic rat model(65 mg/kg

ip) was established. In the telmisartan treatment group

the rats were treated with telmisartan (13.3 mg·kg

-1

·d

-1

) for 12 weeks. Learning and memory abilities of the rats were tested by the Morris water maze. The mRNA and protein levels of GHSR in frontal cortex were detected by RT-PCR and immunohistochemistry

. Results Compared with the diabetic model group

the telmisartan treatment group showed a significant decrease in the mean time of escape latencies(P0.05)and an increased percentage of time spent in the central area and the more times navigating the original platform position(P0.05). The mRNA and protein expressions of GHSR were elevated significantly in frontal cortex(P0.05). Conclusion The cognitive dysfunctions induced by diabetes may be correlated with the decrease of GHSR and can be alleviated with telmisartan．

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高原

肖谦

赵柯湘

吴绮楠

李龙英

高爱滨

张海娜

LIU Dong

Related Institution

Department of Immunology, Faculty of Pharmacy and Laboratory Medicine， Army Medical University （Third Military Medical University）

Department of Laboratory Animal Science， College of Basic Medical Sciences, Faculty of Pharmacy and Laboratory Medicine， Army Medical University （Third Military Medical University）

Department of Pharmaceutical Analysis, Faculty of Pharmacy and Laboratory Medicine， Army Medical University （Third Military Medical University）

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