Expressions and clinical significances of c-Met, MMP-2, MMP-9 in metastasis of human hepatocellular carcinoma: report of 47 cases

谢斌; 唐春; 吴刚; 陈平

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Expressions and clinical significances of c-Met, MMP-2, MMP-9 in metastasis of human hepatocellular carcinoma: report of 47 cases

更新时间：2026-01-09

- Expressions and clinical significances of c-Met, MMP-2, MMP-9 in metastasis of human hepatocellular carcinoma: report of 47 cases
- Journal of Army Medical University Vol. 30, Issue 12, Pages: 1140-1143(2008)
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  CLC： R394.2;R730.23;R735.7
- Published：2008
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谢斌,唐春,吴刚,陈平.c-Met、MMP-2、MMP-9在肝细胞癌中的表达及临床意义[J].陆军军医大学学报(原第三军医大学学报),2008,30(12):1140-1143.

　XIE Bin,TANG Chun,WU Gang,CHEN Ping.Expressions and clinical significances of c-Met, MMP-2, MMP-9 in metastasis of human hepatocellular carcinoma: report of 47 cases[J].J Amry Med Univ (J Third Mil Med Univ),2008,30(12):1140-1143.
谢斌,唐春,吴刚,陈平.c-Met、MMP-2、MMP-9在肝细胞癌中的表达及临床意义[J].陆军军医大学学报(原第三军医大学学报),2008,30(12):1140-1143. DOI：

　XIE Bin,TANG Chun,WU Gang,CHEN Ping.Expressions and clinical significances of c-Met, MMP-2, MMP-9 in metastasis of human hepatocellular carcinoma: report of 47 cases[J].J Amry Med Univ (J Third Mil Med Univ),2008,30(12):1140-1143. DOI：

摘要

目的研究c-Met、基质金属蛋白酶-2（matrix metalloproteinase-2

MMP-2）、基质金属蛋白酶-9（matrix metalloproteinase-9

MMP-9）在肝细胞癌（hepatocellular carcinoma

HCC）中的表达，探讨三者的表达与肝癌侵袭转移间的关系，并初步明确在肝细胞癌预后判断中的作用。方法采用免疫组化对47例肝细胞癌手术切除标本中c-Met、MMP-2、MMP-9的表达进行检测，评估c-Met的表达与HCC临床病理因素的关系及与MMP-2、MMP-9表达的关系。结果 c-Met、MMP-2、MMP-9在肝细胞癌组织中的阳性表达率分别为38.3%、72.3%、89.4%，与正常肝组织比较差异有统计学意义(分别为12%、16%、12%，P0.05）；c-Met阳性表达率与肝细胞癌的转移、淋巴浸润、包膜形成以及肿瘤分化有关（P0.05），而与性别、年龄、肿瘤的大小、分期无关；MMP-2的阳性表达率仅与肝细胞癌的包膜形成有关（P=0.028）；MMP-9的阳性表达率与HCC的各项临床病理因素无关; c-Met阳性表达与MMP-2的异常表达有关（P0.001）。结论在HCC的转移中， HGF/c-Met与HCC的转移有关，并且与MMP系统之间存在联系，可能影响MMP-2、MMP-9的表达，对于HCC的转移防治及预后具有一定的临床意义。

Abstract

Objective To investigate the expressions of c-Met

MMP-2

MMP-9 in the invasion

metastasis and prognosis of hepatocellular carcinoma(HCC). Methods We used immunohistochemistry to evaluate the expressions of c-Met

MMP-2

and MMP-9

and statistically analyzed the relationship between these expressions and clinicopathological prognostic parameters in 47 patients with HCC. Another 25 samples taken 3 cm away from the margin of tumor mass served as control. Results The results showed that the positive rates of the expression of c-Met

MMP-2

MMP-9 in HCC tissue samples were 38.3%

72.3% and 89.4% respectively

but in normal liver tissue were 12%

16% and 12% respectively. The expression of c-Met was significantly higher in HCC than in normal liver tissue

while the expressions of MMP-2 and MMP-9 were significantly higher in HCC than in normal liver tissue. c-Met expression was correlated with lymph node status

capsule

metastasis (intra- or extra-hepatic metastasis) and histological grade

but not with gender

age

tumor size

and stage of the disease

similarly MMP-2

MMP-9 expressions were correlated with capsule

but not with gender

age

tumor size

lymph node status

neoplasm stage and histological grade. A statistical significant correlation was found between c-Met and abnormal MMP-2 expression (P0.01). Conclusion These results suggest that c-Met may be involved in the up-regulation of MMP-2

via interaction of HGF/c-Met signal pathway and MMPs

which may plays an important role in the invasion

metastasis and prognosis of HCC.

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