Effects of hydroxyethyl starch at different molecular weights on hemorrhagic shock in rats

李涛; 方玉强; 刘良明; 杨成民

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Effects of hydroxyethyl starch at different molecular weights on hemorrhagic shock in rats

更新时间：2026-01-09

- Effects of hydroxyethyl starch at different molecular weights on hemorrhagic shock in rats
- Journal of Army Medical University Vol. 30, Issue 14, Pages: 1319-1321(2008)
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  CLC： R457;R605.971;R977.6
- Published：2008
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李涛,方玉强,刘良明,杨成民.羟乙基淀粉对失血性休克大鼠复苏效果的影响[J].陆军军医大学学报(原第三军医大学学报),2008,30(14):1319-1321.

　LI Tao,FANG Yu-qiang,LIU Liang-ming,YANG Cheng-min.Effects of hydroxyethyl starch at different molecular weights on hemorrhagic shock in rats[J].J Amry Med Univ (J Third Mil Med Univ),2008,30(14):1319-1321.
李涛,方玉强,刘良明,杨成民.羟乙基淀粉对失血性休克大鼠复苏效果的影响[J].陆军军医大学学报(原第三军医大学学报),2008,30(14):1319-1321. DOI：

　LI Tao,FANG Yu-qiang,LIU Liang-ming,YANG Cheng-min.Effects of hydroxyethyl starch at different molecular weights on hemorrhagic shock in rats[J].J Amry Med Univ (J Third Mil Med Univ),2008,30(14):1319-1321. DOI：

摘要

目的比较不同相对分子质量的6%羟乙基淀粉（hydroxyethyl starch

HES）/0.9% NaCl溶液对大鼠失血性休克的复苏效果。方法 SD大鼠制作45%放血失血性休克模型，观察相对分子质量为40、130、200的HES40、HES130、HES200对休克动物平均动脉血压（mean arterial blood pressure

MAP）、血流动力学和血气指标的影响，同时观察存活时间和24 h存活率，并以万汶和贺斯作为对照组。结果自制不同相对分子质量HES可以改善MAP、左心室收缩压（left intraventricular systolic pressure

LVSP)、左心室压力上升或下降的最大速率(maximal change rate of left intraventricular pressure

±dp/dt

max

)等血流动力学指标，效果与血气贺斯组相当，HES130和HES200组动物存活时间略高于HES40，其中以HES200效果最好，与万汶和贺斯效果相当。结论 3种不同相对分子质量的HES均具有明显抗失血性休克作用，其中以HES200效果更明显。

Abstract

Objective To compare the resuscitation effect of 6% hydroxyethyl starch (HES) of different molecular weight in normal saline on hemorrhagic shock in rats. Methods Hemorrhagic shock model was established in 50 SD rats by 45% hemorrhage

and then they were equally divided into 5 groups. The rats were administered with HES40/

HES130/

HES200/normal saline

Voluven or Haes. Their mean arterial blood pressure (MAP)

left intraventricular systolic pressure (LVSP)

the maximal change rate of left intraventricular pressure (±dp/dt

max

)

of hemorrhagic shock rat were observed. Meanwhile

the artery blood gas

the survival time and 24-hour survival rate were also observed. Results Similar hemodynamic parameters values were obtained in the rats treated with our HES and those with Voluven or Haes. HES130 and HES200 prolonged the survival time of shocked animals in comparison with HES40. Among the 3 types of HES

HES200 had the best effect

which is equivalent to Voluven and Haes. Conclusion HES of 3 molecular weights have beneficial effect on hemorrhagic shock

and HES200 exerts best.

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