Resveratrol protects against peroxide toxicity in rats induced by arsenic trioxide

刘中禄; 毕玉田; 袁军

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Resveratrol protects against peroxide toxicity in rats induced by arsenic trioxide

更新时间：2026-01-09

- Resveratrol protects against peroxide toxicity in rats induced by arsenic trioxide
- Journal of Army Medical University Vol. 30, Issue 18, Pages: 1690-1692(2008)
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  CLC： R595.05;R979.3;R995
- Published：2008
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刘中禄,毕玉田,袁军.白藜芦醇减轻三氧化二砷所致大鼠过氧化毒性作用[J].陆军军医大学学报(原第三军医大学学报),2008,30(18):1690-1692.

　LIU Zhong-lu,BI Yu-tian,YUAN Jun.Resveratrol protects against peroxide toxicity in rats induced by arsenic trioxide[J].J Amry Med Univ (J Third Mil Med Univ),2008,30(18):1690-1692.
刘中禄,毕玉田,袁军.白藜芦醇减轻三氧化二砷所致大鼠过氧化毒性作用[J].陆军军医大学学报(原第三军医大学学报),2008,30(18):1690-1692. DOI：

　LIU Zhong-lu,BI Yu-tian,YUAN Jun.Resveratrol protects against peroxide toxicity in rats induced by arsenic trioxide[J].J Amry Med Univ (J Third Mil Med Univ),2008,30(18):1690-1692. DOI：

摘要

目的探讨白藜芦醇（resveratrol

RES）减轻三氧化二砷对大鼠的毒性作用。方法腹腔注射三氧化二砷连续4周，治疗组在注射三氧化二砷前给予 RES 30、60、120 mg·kg

-1

·d

-1

。4周后取动物血清、肝、肺、脾及脑组织测定超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)、丙二醛(MDA)、NO含量。结果与正常对照组相比，三氧化二砷引起动物血清、肝、肺、脾及脑组织NO和MDA水平显著增高，SOD和GSH-Px含量明显下降。RES治疗后显著改善三氧化二砷引起的上述变化，血清和肝、肺、脾及脑组织MDA、NO含量降低，而且总SOD、GSH-Px的活力均有明显升高，RES的作用呈剂量依赖性。结论 RES可保护抗过氧化酶活性和抑制过氧化物产生。

Abstract

Objective To study the effects of resveratrol against toxicity induced by arsenic trioxide in rats. Methods Arsenic trioxide was given to SD rats intraperitoneally for 4 weeks. Resveratrol was injected intraperitoneally to the animals 4 h before arsenic trioxide challenge at dose of 30

or 120 mg·kg

-1

·d-1. Four weeks later

the contents of malondialdehyde (MDA)

superoxide dismutase (SOD)

nitric oxide (NO)

glutathione peroxidase (GSH-Px) in serum

lung

spleen

liver and brain tissues were measured. Results Compared with the normal control rats

arsenic trioxide challenge resulted in increases of NO and MDA contents in serum

lung

spleen

liver and brain tissues

and decreas

es of GSH-Px and SOD levels in the rats received arsenic trioxide only. Resveratrol significantly inhibited these changes induced by arsenic trioxide in rat serum

lung

spleen

liver and brain tissues in a dose-dependent manner. Conclusion Resveratrol can protect antiperoxidase activity and inhibit peroxide productions.

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