Objective  To study the function of urokinase plasminogen activator receptor (uPAR) in the course of reepithelialization after wound by local recombinant plasmid injection and electroporation.    Methods  Thirty-six BALB/c mice were divided into three groups: wound only group

blank plasmid group and pEGFPC1-uPAR plasmid group. The recombinant pEGFPC1-uPAR was by electroporation injected intradermally at two sites around each wound. The healing rate of wound and the quality of wound healing were calculated to evaluate the cutaneous re-epithelialization on day 1

3

6

9

14

17 after trauma.    Results  As compared with control mice

the healing rate of wound in the uPAR transfected mice was higher; the granulation tissues were of little change; the content of collagen increased at the early stage; the proliferation and migration of epidermis were enhanced.    Conclusion  The recombinant uPAR plasmid intradermally injected by electroporation can promote the cutaneous re-epithelialization after wound.