Postnatal development and perinatal electrophysiological characteristics of oligodendrocyte precursor cell in rats

陈鹏慧; 蔡文琴; 王丽雁

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Postnatal development and perinatal electrophysiological characteristics of oligodendrocyte precursor cell in rats

更新时间：2026-01-09

- Postnatal development and perinatal electrophysiological characteristics of oligodendrocyte precursor cell in rats
- Journal of Army Medical University Vol. 30, Issue 19, Pages: 1783-1786(2008)
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  CLC： R329.25;R338.1;R338.8
- Published：2008
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陈鹏慧,蔡文琴,王丽雁.大鼠少突胶质细胞前体细胞的生后发育特点及围生期电生理特性的研究[J].陆军军医大学学报(原第三军医大学学报),2008,30(19):1783-1786.

　CHEN Peng-hui,CAI Wen-qin,WANG Li-yan.Postnatal development and perinatal electrophysiological characteristics of oligodendrocyte precursor cell in rats[J].J Amry Med Univ (J Third Mil Med Univ),2008,30(19):1783-1786.
陈鹏慧,蔡文琴,王丽雁.大鼠少突胶质细胞前体细胞的生后发育特点及围生期电生理特性的研究[J].陆军军医大学学报(原第三军医大学学报),2008,30(19):1783-1786. DOI：

　CHEN Peng-hui,CAI Wen-qin,WANG Li-yan.Postnatal development and perinatal electrophysiological characteristics of oligodendrocyte precursor cell in rats[J].J Amry Med Univ (J Third Mil Med Univ),2008,30(19):1783-1786. DOI：

摘要

目的研究少突胶质细胞前体细胞（OPC）的发育特点及围生期电生理特性。方法应用免疫组化及Western blot，观察生后不同发育阶段大鼠大脑皮质、海马等区域OPC细胞数量。应用脑片膜片钳记录出生后7 d大鼠皮层白质和海马OPC电生理学特性。结果出生后0、7、14、21、35、50 d、18个月大鼠大脑皮层及海马区域均有OPC细胞表达。在发育生后7d，细胞数量密度最高，成年大鼠也有较高数量OPC的分布。P7d大鼠海马OPC有小的内向Na

电流，而白质区域OPC仅表现外向K

电流和细胞膜被动反应。结论 P7d大鼠皮层及海马区域OPC细胞数量及NG2蛋白表达量最大，海马和白质区域的OPC表现电生理学特性的异质性。

Abstract

Objective To observe the postnatal development and perinatal electrophysiological characteristics of oligodendrocyte precursor cell (OPC) in rats. Methods Immunohistochemistry and Western blot were applied to determine the expression of NG2 OPC in cerebral cortex and hippocampus at various developmental stages of SD rats. Electrophysiological characteristics of OPC were also recorded in slices of 7-day rats. Results The majority of hippocampal and cerebral OPC exhibited stellate shape

a small cell body with a few processus. Total population of the NG2 immunopositive OPC was numerous at P7d in cerebral cortex and hippocampus. OPC expressed in adult rats with slightly more quantity. Moreover

OPC in hippocampus of P7d rats typically exhibited small inward sodium current and weak active responses

whereas only outward potassium current and inactive responses were recorded in white matter OPC of P7d rats. Conclusion Total population of OPC and relative optical density of NG2 are the highest in P7d rats at the postnatal developmental stages. OPC in cerebrum and hippocampus of P7d rats displays electrophysiological heterogeneity.

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State Key Laboratory of Trauma, Burns and Combined Injury, Laboratory for Rehabilitation of Traumatic Injuries, Laboratory for Prevention and Rehabilitation of Military Training Related Injury, Institute of Surgery Research, Daping Hospital, Army Medical University (Third Military Medical University)

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