Roles of renin-angiotension system in cardiac mechanics and myocardial damage at early stage following severe scald in rats

雷泽源; 黄跃生; 肖蓉; 张兵钱; 张琼

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Roles of renin-angiotension system in cardiac mechanics and myocardial damage at early stage following severe scald in rats

更新时间：2026-01-09

- Roles of renin-angiotension system in cardiac mechanics and myocardial damage at early stage following severe scald in rats
- Journal of Army Medical University Vol. 30, Issue 19, Pages: 1779-1782(2008)
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  CLC： R322.11;R329.25;R644
- Published：2008
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雷泽源,黄跃生,肖蓉,张兵钱,张琼.大鼠严重烧伤早期RAS的变化对心功能及心肌损害的影响[J].陆军军医大学学报(原第三军医大学学报),2008,30(19):1779-1782.

　LEI Ze-yuan,HUANG Yue-sheng,XIAO Rong,ZHANG Bing-qian,ZHANG Qiong.Roles of renin-angiotension system in cardiac mechanics and myocardial damage at early stage following severe scald in rats[J].J Amry Med Univ (J Third Mil Med Univ),2008,30(19):1779-1782.
雷泽源,黄跃生,肖蓉,张兵钱,张琼.大鼠严重烧伤早期RAS的变化对心功能及心肌损害的影响[J].陆军军医大学学报(原第三军医大学学报),2008,30(19):1779-1782. DOI：

　LEI Ze-yuan,HUANG Yue-sheng,XIAO Rong,ZHANG Bing-qian,ZHANG Qiong.Roles of renin-angiotension system in cardiac mechanics and myocardial damage at early stage following severe scald in rats[J].J Amry Med Univ (J Third Mil Med Univ),2008,30(19):1779-1782. DOI：

摘要

目的研究烧伤早期RAS对心功能及心肌损伤的影响。方法健康雄性Wistar大鼠42只，随机数字法分为对照组（正常组，假伤组）和烧伤组，在大鼠30% TBSA Ⅲ度烧伤后1、3、6、12、24 ｈ检测血清AngⅡ，ACE，cTn-I和心肌组织AngⅡ，ACE，ACE2含量变化及血流动力和心肌力学指标(SBP

DBP

LVSP

LVEDP

+LVdp/dt

max

，-LVdp/dt

max

)

Western blot检测心肌组织中ACE2表达。结果烧伤后1 h开始LVSP

+LVdp/dt

max

，-LVdp/dt

max

较对照组均明显降低(P0.01)，LVEDP明显增高(P0.01)，并于6 h达到高峰，血清中cTn-I，AngⅡ，ACE和心肌组织中的AngⅡ，ACE，1 h开始较对照组明显增高(P0.01)，6 h达到峰值；而心肌组织中的ACE2在烧伤前后无明显变化。结论 ACE-AngⅡ轴的变化趋势与血流动力、心肌力学指标及血清cTn-I变化相一致，提示RAS中重要效应轴ACE-AngⅡ轴在烧伤早期心肌损害中起着重要作用。烧伤后ACE2无明显变化，可能是导致ACE-AngⅡ轴过度激活的原因之一。

Abstract

Objective To investigate the changes of RAS and its effects to heart function and myocardial damage at early stage of rat scald. Methods The rats were grouped as control group (normal group and sham scald group

totally n=12) and scalded group (n=30). The rat model of 30% TBSA of full-thickness burns was made in 30 male Wistar rats. Hemodynamics and myocardiac mechanics index (SBP

DBP

LVSP

LVEDP

+LVdp/dt

max

-LVdp/dt

max

)

cTn-I

AngⅡ

E levels in serum

and AngⅡ

ACE

ACE2 in myocardium were determined 1

24 h after scald. Results Compared with control group

LVSP

+LVdp/dt

max

-LVdp/dt

max

were decreased obviously 1 h after scald (P0.01)

whereas LVEDP increased significantly 1 h after scald (P0.01)

and peaked 6 h after scald. The levels of cTn-I

AngⅡ

ACE in serum

and AngⅡ and ACE in myocardium were increased obviously 1 h after scald (P0.01) compared with control group

and peaked 6 h after scald. No obvious changes of myocardiac ACE2 were detected before and after scald. Conclusion The changing tendency of ACE-AngⅡ axis similar to that of hemodynamic index and serum level of cTn-I indicted that ACE-AngⅡ axis of RAS plays an important role in myocardial damage at the early stage after scald. No obvious changes of ACE2 before and after scald may be one of the reasons to activate ACE-AngⅡ axis.

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