Role of 1,25-Dihydroxyvitamin D<sub>3</sub> treated dendritic cells in allergic airway inflammation

夏俊波; 宋云熙; 曾雪峰; 王彦; 王长征

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Role of 1,25-Dihydroxyvitamin D₃ treated dendritic cells in allergic airway inflammation

更新时间：2026-01-09

- Role of 1,25-Dihydroxyvitamin D₃ treated dendritic cells in allergic airway inflammation
- Journal of Army Medical University Vol. 30, Issue 8, Pages: 743-745(2008)
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  CLC： R392.12;R562.2;R977.24
- Published：2008
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夏俊波,宋云熙,曾雪峰,王彦,王长征.1,25-二羟维生素D-3处理树突状细胞在过敏性气道炎症中的作用[J].陆军军医大学学报(原第三军医大学学报),2008,30(08):743-745.

　XIA Jun-bo,SONG Yun-xi,ZENG Xue-feng,WANG Yan,WANG Chang-zheng.Role of 1,25-Dihydroxyvitamin D3 treated dendritic cells in allergic airway inflammation[J].J Amry Med Univ (J Third Mil Med Univ),2008,30(08):743-745.
夏俊波,宋云熙,曾雪峰,王彦,王长征.1,25-二羟维生素D-3处理树突状细胞在过敏性气道炎症中的作用[J].陆军军医大学学报(原第三军医大学学报),2008,30(08):743-745. DOI：

　XIA Jun-bo,SONG Yun-xi,ZENG Xue-feng,WANG Yan,WANG Chang-zheng.Role of 1,25-Dihydroxyvitamin D3 treated dendritic cells in allergic airway inflammation[J].J Amry Med Univ (J Third Mil Med Univ),2008,30(08):743-745. DOI：

摘要

目的〖HTSS〗研究1

25-二羟维生素D

对树突状细胞（dendritic cells

DC）表型和功能的影响及其处理后DC在过敏性气道炎症中的作用。方法体外扩增小鼠骨髓来源的树突状细胞，采用流式细胞术和ELISA检测1

25-二羟维生素D

对DC表型和分泌细胞因子IL-10和IL-12的影响；观察1

25-二羟维生素D

处理DC过继卵蛋白致敏小鼠肺组织病理特点和支气管肺泡灌洗液细胞类型。结果经1

25-二羟维生素D

处理后，DC表达CD80和 MHCⅡ均明显降低，而CD11c变化不明显；分泌IL-10显著增加，而分泌IL-12显著降低。过继小鼠肺组织未见典型的哮喘样病理改变，支气管肺泡灌洗液细胞类型与空白对照组无显著差异。结论 1

25-二羟维生素D

可抑制DC成熟，经其处理后DC过继致敏小鼠可诱导对抗原的免疫耐受，避免过敏性气道炎症的发生。

Abstract

Objective To study the effect of 1

25-Dihydroxyvitamin D

on the phenotype of dendritic cells (DC) and their function and the role of 1

25-Dihydroxyvitamin D

treated DC in asthmatic airway inflammation. Methods DC were harvested by differentiating mouse borrow cells in vitro. The effect of 1

25-Dihydroxyvitamin D

on phenotype of DC and their secretion of cytokines IL-10 and IL-12 was determined by flow cytometry and ELISA. Pathological changes and bronchoalveolar lavage fluid (BALF) cell types of OVA-sensitized mouse transferred by 1

25-Dihydroxyvitamin D

eated DC were observed. Results After DCs were treated by 1

25-Dihydroxyvitamin D

the expressions of CD80 and MHCⅡ were decreased

whereas the expressions of CD11c were not changed. The secretion of IL-10 was increased

but that of IL-12 was decreased. Typical pathological changes of asthma were not seen in lung tissues of transferred mouse. The BALF cell types were not significantly changed as compared with blank control. Conclusion 1

25-Dihydroxyvitamin D

inhibits DC maturation. Adoptive transfer of DCs treated with 1

25-Dihydroxyvitamin D

into OVA-sensitized mouse induces antigen-specific immune tolerance

avoiding the onset of asthmatic airway inflammation.

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Role of 1,25-Dihydroxyvitamin D3 treated dendritic cells in allergic airway inflammation

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摘要

Abstract

关键词

Keywords

references

Role of 1,25-Dihydroxyvitamin D₃ treated dendritic cells in allergic airway inflammation