Objective   To measure the retinal nerve fiber layer thickness (RNFLT) in myopic patients and explore the association between diopter

corrected vision

central cornea thickness (CCT) and RNFLT in myopia.    Methods  The present study consisted of randomly selected 90 myopic patients (90 eyes)

dividing into 3 groups according to their diopters: low myopia (≤-3.00 D

14 eyes)

moderate myopia (-6.00 to -3.00 D

47 eyes) and severe myopia (-6.00  D

29 eyes). RNFLT was measured with optical coherence tomography (OCT3000

RNFLT 3.4) and CCT with Pachymeter-SP-3000. All patients underwent mydriasis and subsequent optometry.    Results  Age

sex

corrected vision

CCT

superior (S)

inferior (I) and nasal (N) RNFLT had no significant difference among the 3 groups (P0.05)

but temple (T) RNFLT  was of significant difference between low and severe myopia groups by ANOVA (P=0.012). The changing pattern of RNFLT in myopia follows the rule of “ISTN”. Except the average (Avg)-RNFLT had positive correlation with diopter in severe myopia group (r=0.372

P=0.047)

no significant correlation was observed in other parameters among three groups.    Conclusion  RNFLT in myopia measured by OCT may have its own rule. Avg-RNFLT may have positive correlation with diopter in severe myopia group.