Combined determination of tumor markers in serum and bronchoalveolar lavage fluid for lung cancer diagnosis

邓丽平; 董文; 杜艳萍; 江兴堂

您当前的位置：

首页 >

文章列表页 >

Combined determination of tumor markers in serum and bronchoalveolar lavage fluid for lung cancer diagnosis

更新时间：2026-01-09

- Combined determination of tumor markers in serum and bronchoalveolar lavage fluid for lung cancer diagnosis
- Journal of Army Medical University Vol. 30, Issue 1, Pages: 78-80(2008)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：
  CLC： R730.43;R734.2
- Published：2008
- 稿件说明：
移动端阅览
邓丽平,董文,杜艳萍,江兴堂.支气管肺泡灌洗液和血清肿瘤标志物联合检测在肺癌诊断中的价值[J].陆军军医大学学报(原第三军医大学学报),2008,30(01):78-80.

　DENG Li-ping,DONG Wen,DU Yan-ping,JIANG Xing-tang.Combined determination of tumor markers in serum and bronchoalveolar lavage fluid for lung cancer diagnosis[J].J Amry Med Univ (J Third Mil Med Univ),2008,30(01):78-80.
邓丽平,董文,杜艳萍,江兴堂.支气管肺泡灌洗液和血清肿瘤标志物联合检测在肺癌诊断中的价值[J].陆军军医大学学报(原第三军医大学学报),2008,30(01):78-80. DOI：

　DENG Li-ping,DONG Wen,DU Yan-ping,JIANG Xing-tang.Combined determination of tumor markers in serum and bronchoalveolar lavage fluid for lung cancer diagnosis[J].J Amry Med Univ (J Third Mil Med Univ),2008,30(01):78-80. DOI：

摘要

目的探讨支气管肺泡灌洗液和血清中肿瘤标志物，癌胚抗原(carcinoembryonic antigen

CEA)、细胞角质蛋白19片段(cytokeratin 19 fragment

CYFRA21-1)、神经元烯醇化酶(neuron-specific enolase

NSE)在肺癌早期诊断中的临床价值。方法采用电化学发光法测定70例肺癌住院患者及40例肺部良性疾病患者支气管肺泡灌洗液和血清中CEA、NSE、CYFRA21-1水平。结果肺癌患者支气管肺泡灌洗液和血清3项肿瘤标志物平均含量均高于肺部良性疾病患者(P0.01)。支气管肺泡灌洗液中3种标志物的含量明显高于血清中的含量(P0.05)。联合检测两项及3项阳性者均使支气管肺泡灌洗液和血清诊断肺癌的敏感性和准确性得到提高。Ⅲ、Ⅳ期肺癌组支气管肺泡灌洗液和血清中3项肿瘤标志物的表达水平均高于Ⅰ+Ⅱ期患者(TNM 分期)，Ⅰ＋Ⅱ期肺癌组支气管肺泡灌洗液中3项肿瘤标志物的表达水平高于肺良性病组(P0.05)。结论支气管肺泡灌洗液CEA、CYFRA21-1、NSE检测对肺癌的早期诊断价值优于血清，联合检测支气管肺泡灌洗液和血清中的肿瘤标志物能大大提高临床诊断肺癌的阳性率。

Abstract

Objective To investigate the clinical value of bronchoalveolar lavage fluid (BALF) and serum tumor markers including carcinoembryonic antigen(CEA)

cytokeratin 19 fragment (CYFRA21-1) and neuron-specific enolase (NSE) for the diagnosis of lung cancer. Methods The levels of above mentioned tumor markers in the BALF and serum samples of 70 patients with pathologically diagnosed lung cancer and 40 patients with benign lung diseases (BLD) were measured by electrochemiluminescence. Results The levels of 3 tumor markers in the BALF and serum were significantly higher in cancer patients than those with BLD (P0.01)

and the levels in BALF were significantly higher than those in the serum (P0.05). The sensitivity and accuracy of diagnosing lung cancer were increased when 2 or 3 markers in BALF and serum were detected in combination. The levels of 3 tumor markers in the BALF and the serum were higher in stage Ⅲ or Ⅳ of cancer patients than in stageⅠand stage Ⅱ (TNM stage). Conclusion In diagnosis of lung cancer CEA

CYFRA21-1

and NSE levels in the BALF have more important clinical significance than those in the serum. Combined determination of these tumor markers can increase the sensitivity and the accuracy

and might be useful to the diagnosis of lung cancer.

关键词

Keywords

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Highly sensitive detection of tumor markers CEA and CYFRA21-1 for lung cancer based on gold nanoparticle probes and protein chip

Genome-wide screening of tumor suppressor genes in oncogenic transformation of normal lung epithelial cells and preliminary validation in sample databases

Differences in CT findings between solid solitary mucinous lung invasive adenocarcinoma and non-mucinous lung invasive adenocarcinoma

Effect of TET1 gene expression on migration and invasion in lung cancer cells

Metformin attenuates biological electric field-induced migration and proliferation of lung cancer cells by inhibiting AKT pathway

Related Author

王文涛

贾春平

金庆辉

赵建龙

张国俊

Binyu ZHAO

Junlei ZHANG

Jiaqi WANG

Related Institution

Department of Physiology, College of Basic Medical Sciences, Army Medical University (Third Military Medical University)

Department of Histology and Embryology, College of Basic Medical Sciences, Army Medical University (Third Military Medical University)

Teaching Experiment Center, College of Basic Medical Sciences, Army Medical University (Third Military Medical University)

Department of Ophthalmology, First Affiliated Hospital, Army Medical University (Third Military Medical University)

Department of Radiology, the First Affiliated Hospital of Chongqing Medical University

⁰