Association of adiponectin gene Gly15Gly polymorphism with primary macroangiopathy in diabetes mellitus

艾智华; 房殿春; 张忠辉

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Association of adiponectin gene Gly15Gly polymorphism with primary macroangiopathy in diabetes mellitus

更新时间：2026-01-09

- Association of adiponectin gene Gly15Gly polymorphism with primary macroangiopathy in diabetes mellitus
- Journal of Army Medical University Vol. 30, Issue 6, Pages: 536-538(2008)
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  CLC： R341;R394.3;R587.2
- Published：2008
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艾智华,房殿春,张忠辉.脂联素基因Gly15Gly多态性与糖尿病大血管病变的关系[J].陆军军医大学学报(原第三军医大学学报),2008,30(06):536-538.

　AI Zhi-hua,FANG Dian-chun,ZHANG Zhong-hui.Association of adiponectin gene Gly15Gly polymorphism with primary macroangiopathy in diabetes mellitus[J].J Amry Med Univ (J Third Mil Med Univ),2008,30(06):536-538.
艾智华,房殿春,张忠辉.脂联素基因Gly15Gly多态性与糖尿病大血管病变的关系[J].陆军军医大学学报(原第三军医大学学报),2008,30(06):536-538. DOI：

　AI Zhi-hua,FANG Dian-chun,ZHANG Zhong-hui.Association of adiponectin gene Gly15Gly polymorphism with primary macroangiopathy in diabetes mellitus[J].J Amry Med Univ (J Third Mil Med Univ),2008,30(06):536-538. DOI：

摘要

目的探讨脂联素基因Gly15Gly多态性与糖尿病早期大血管病变发生的关系。方法运用多聚酶链式反应-限制性片段长度基因多态性（PCR-RFLP法）分析方法，对56例伴大血管病变和120例无大血管病变的2型糖尿病患者脂联素基因Gly15Gly多态性位点进行基因分型。结果大血管病变组GG基因型频率(25.0%)显著高于无血管病变组(6.2%)，G等位基因频率显著升高(P0.05)；GG基因型血浆脂联素水平显著低于TT和TG基因型。结论脂联素基因Gly15Gly多态性与糖尿病大血管并发症的发生有关，脂联素基因+45位点GG基因型是2型糖尿病大血管并发症的易感基因型。

Abstract

Objective To investigate the association adiponectin gene polymorphism with primary macroangiopathy in diabetes mellitus. Methods Type 2 diabetes mellitus (T2DM) patients were included

56 patients complicated with atherosclerosis (AS) and 120 non-AS group. We evaluated their Gly15Gly polymorphism of adiponectin gene by PCR restriction fragment length polymorphism (PCR-RFLP). Results The AS patients were more likely to have GG genotype than the non-AS patients (25.0% vs 6.2%

P0.05). Blood adiponectin in the patients with GG genotype was lower than that in ones with TT or TG genotype [(15.10±7.04) g/ml vs (19.64±6.64) g/ml and (18.38±7.49) g/ml]. Conclusion Gly15Gly polymorphism of adiponectin gene is related to primary macrovascular complications in T2DM. GG genotype is probably the predisposing gene for primary macrovascular complications in T2DM.

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