Prostaglandin E<sub>2</sub> in peripheral blood and tumor mass of patients with gastric cancer

俞慧宏; 吴小翎; 张苜; 宁波

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Prostaglandin E₂ in peripheral blood and tumor mass of patients with gastric cancer

更新时间：2026-01-09

- Prostaglandin E₂ in peripheral blood and tumor mass of patients with gastric cancer
- Journal of Army Medical University Vol. 30, Issue 5, Pages: 444-446(2008)
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  CLC： R730.23;R730.43;R735.2
- Published：2008
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俞慧宏,吴小翎,张苜,宁波.测定胃癌患者肿瘤组织与外周血中前列腺素E2的临床意义[J].陆军军医大学学报(原第三军医大学学报),2008,30(05):444-446.

　YU Hui-hong,WU Xiao-ling,ZHANG Mu,NING Bo.Prostaglandin E2 in peripheral blood and tumor mass of patients with gastric cancer[J].J Amry Med Univ (J Third Mil Med Univ),2008,30(05):444-446.
俞慧宏,吴小翎,张苜,宁波.测定胃癌患者肿瘤组织与外周血中前列腺素E2的临床意义[J].陆军军医大学学报(原第三军医大学学报),2008,30(05):444-446. DOI：

　YU Hui-hong,WU Xiao-ling,ZHANG Mu,NING Bo.Prostaglandin E2 in peripheral blood and tumor mass of patients with gastric cancer[J].J Amry Med Univ (J Third Mil Med Univ),2008,30(05):444-446. DOI：

摘要

目的测定胃癌患者肿瘤组织及外周血中前列腺素E

（prostaglandin E

，PGE

）含量。方法用PGE

酶联免疫试剂盒分别测定40例胃癌患者肿瘤组织、癌旁切缘组织及术前外周血中PGE

含量。结果胃癌组织的PGE

含量明显高于癌旁切缘组织，分别为（8.225±2.425）、（1.669±0.287）ng/g，两者差异有统计学意义（P0.01）

低分化和高中分化胃癌组织PGE

含量分别为（9.02±2.28）、（5.38±0.35）ng/g，两者有显著性差异（P0.05）。外周血中PGE

含量与胃癌组织PGE

含量呈正相关（r=0.889，P0.01）。肿瘤直径≥5 cm和＜5 cm的胃癌患者外周血中PGE

含量差异有统计学意义（P0.05）。低分化和高中分化胃癌患者外周血中PGE

含量差异也有统计学意义（P0.05）。胃癌组织及外周血中PGE

含量与患者年龄、性别无关，与肿瘤部位、浸润深度、临床病理分期及是否淋巴结转移也无关。结论胃癌患者肿瘤组织中PGE

含量增高，其外周血PGE

含量也随之增高，表明外周血PGE

水平与胃癌组织释放的PGE

含量成正比。测定外周血中PGE

可以间接评估胃癌患者的肿瘤大小与分化程度。

Abstract

Objective To assess the prostaglandin E

(PGE

) levels in tumor mass and peripheral blood of patients with gastric cancer and explore their clinical significance. Methods The PGE

levels in tumor mass

tumor margins of excision and peripheral blood of 40 patients with gastric cancer were measured by a ki

t of PGE

ELISA. Results The PGE

levels were higher in the tissues of gastric cancer than in tumor margins of excision [(8.225±2.425) vs (1.669±0.287) ng/g，P0.01

]

. The PGE

levels in tissues of low and midhigh differentiation cancer were (9.02±2.28) and (5.38±0.35) ng/g respectively

with statistically significance (P0.05). The PGE

levels in peripheral blood was positively correlated to that in tissue of gastric cancer (r=0.889，P0.01). Peripheral blood PGE

level was statistically higher in the tumor more than 5 cm in size than in that less than 5 cm (P0.05)

which were (121.15±38.31) and (78.48±23.76) pg/ml respectively. Statistically significance was observed in the PGE

levels in peripheral blood between low and midhigh differentiation gastric cancers [(115.5±39.17) vs (73.28±17.68) pg/ml

P0.05

]

. There was no significant correlation between different ages

different sexes

site of tumor

depth of invasion

clinopathological type or lymph node involvement. Conclusion The PGE

levels in tumor mass and peripheral blood of patients with gastric cancer are elevated

indicating a positive correlation of the levels in two samples. Peripheral blood PGE

level might be used to evaluate the size and differentiation of tumor. gastric cancer.

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⁰

Prostaglandin E2 in peripheral blood and tumor mass of patients with gastric cancer

DOI：

摘要

Abstract

关键词

Keywords

references

Prostaglandin E₂ in peripheral blood and tumor mass of patients with gastric cancer