Objective To investigate the effect of recombinant human keratinocyte growth factor variant (K102) on mechanical corneal injury in rabbits.  Methods Mechanical corneal injury was made in 108 rabbits surgically. K102 eye drop was given respectively at dose of 0.5

0.25

0.125 mg/ml

taking Beifushu eye drops and Dexamethasone sodium phosphate eye drops as the positive control

and K102 eye drop solvent as the blank control; 4 times per day. Corneal haze was determined with slit lamp microscope and the histopathological changes were observed under light and electron microscope.  Results Three months after operation

the corneal haze was less severe and the average number of corneal cells in shallow 50 μm corneal basement was less than that in Beifushu group and blank group after 0.5 mg/ml K102 treatment. The results of light and electron microscopy showed the epithelial hypertrophy

disorders of cells and collagen arrangement after 0.5 mg/ml K102 treatment were much lighter than that in Beifushu group and blank group.  Conclusion Local application of K102 eye drops reduces the number of stromal keratocyte

then effectively inhibits corneal haze at early stage after mechanical corneal injury in rabbits.