Highly efficient synthesis of marine natural product，24-methylenecholesterol

岳娟娟; 周向东

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Highly efficient synthesis of marine natural product，24-methylenecholesterol

更新时间：2026-01-09

- Highly efficient synthesis of marine natural product，24-methylenecholesterol
- Journal of Army Medical University Vol. 30, Issue 7, Pages: 621-624(2008)
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  CLC： R914.5;R931.77;R977.6
- Published：2008
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岳娟娟,周向东.海洋天然产物24-亚甲基胆固醇的高效合成[J].陆军军医大学学报(原第三军医大学学报),2008,30(07):621-624.

　YUE Juan-juan,ZHOU Xiang-dong.Highly efficient synthesis of marine natural product，24-methylenecholesterol[J].J Amry Med Univ (J Third Mil Med Univ),2008,30(07):621-624.
岳娟娟,周向东.海洋天然产物24-亚甲基胆固醇的高效合成[J].陆军军医大学学报(原第三军医大学学报),2008,30(07):621-624. DOI：

　YUE Juan-juan,ZHOU Xiang-dong.Highly efficient synthesis of marine natural product，24-methylenecholesterol[J].J Amry Med Univ (J Third Mil Med Univ),2008,30(07):621-624. DOI：

摘要

目的高效合成海洋天然产物——24-亚甲基胆固醇。方法以猪去氧胆酸为原料，△

-3β-四氢吡喃氧基-24-酮胆甾烷为关键中间体，异丙基化为关键步骤，经7步反应合成目标分子。结果以66%的总收率合成了目标分子，其结构为MS、IR、

HNMR、

CNMR所证实。结论 24-亚甲基胆固醇的合成，原料易得、路线简短、收率高、符合原子经济性。

Abstract

Objective To synthesize a marine natural product

24-methylenecholesterol. Methods The target molecule was synthesized in 7 steps using hyodeoxycholic acid as the starting material

3β-(tetrahydropyran-2-yloxy)-cholest-5-ene-24-ketone as the key intermediate and isopropylation as the key step. Results The target molecule was synthesized with a total yield of 66% and confirmed by MS

HNMR and

CNMR. Conclusion Our synthesis of 24-methylenecholesterol is characterized by easily acquired starting material

short synthetic route

high yield and atomeconomic.

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