Expressions of BMP-2 and bFGF in synovial tissues of cacroiliac joint in the patients with active ankylosing spondylitis

李建明; 初同伟; 周跃

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Expressions of BMP-2 and bFGF in synovial tissues of cacroiliac joint in the patients with active ankylosing spondylitis

更新时间：2026-01-09

- Expressions of BMP-2 and bFGF in synovial tissues of cacroiliac joint in the patients with active ankylosing spondylitis
- Journal of Army Medical University Vol. 30, Issue 3, Pages: 251-253(2008)
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  CLC： R322.72;{R392.13};R593.230.2
- Published：2008
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李建明,初同伟,周跃.BMP-2和bFGF在强直性脊柱炎活动期骶髂关节滑膜组织中的表达[J].陆军军医大学学报(原第三军医大学学报),2008,30(03):251-253.

　LI Jian-ming,CHU Tong-wei,ZHOU Yue.Expressions of BMP-2 and bFGF in synovial tissues of cacroiliac joint in the patients with active ankylosing spondylitis[J].J Amry Med Univ (J Third Mil Med Univ),2008,30(03):251-253.
李建明,初同伟,周跃.BMP-2和bFGF在强直性脊柱炎活动期骶髂关节滑膜组织中的表达[J].陆军军医大学学报(原第三军医大学学报),2008,30(03):251-253. DOI：

　LI Jian-ming,CHU Tong-wei,ZHOU Yue.Expressions of BMP-2 and bFGF in synovial tissues of cacroiliac joint in the patients with active ankylosing spondylitis[J].J Amry Med Univ (J Third Mil Med Univ),2008,30(03):251-253. DOI：

摘要

目的探讨骨形态发生蛋白2（bone morphogenetic protein-2，BMP-2)和碱性成纤维细胞生长因子（basic fibroblast growth factor， bFGF）在强直性脊柱炎（ankylosing spondylitis，AS）活动期的病理性表达。方法通过免疫组化技术检测活动期AS患者与对照组（骨盆骨折患者）骶髂关节滑膜组织中BMP-2、bFGF的表达，用图像分析系统比较二者的表达差异。结果在AS活动期患者骶髂关节滑膜组织中BMP2和bFGF为阳性表达，而对照组骶髂关节滑膜组织中BMP-2和bFGF为阴性表达，图像灰度值比较二者差异有统计学意义（P0.01）。结论 BMP-2和bFGF均为AS病理性成骨过程中重要的成骨因子，它们与强直性脊柱炎骶髂关节成骨硬化过程有密切关系。

Abstract

Objective To investigate the expressions of BMP-2 and bFGF in ankylosing spondylitis (AS) patients in active stage. Methods Five patients with active AS were admitted from July 2006 to March 2007

including 4 males and 1 female

with average age of 31.4 years. Five patients with pelvic fracture served as control

including 3 males and 2 females

with average age of 34.5 years. Using immunohistochemistry

the expressions of BMP-2 and bFGF were detected in the frozen synovial tissues of cacroiliac joint in active AS patients and in the pelvic fracture patients

and the results were compared by analyzing the gray scale of the pictures. Results The positive expressions of BMP-2 and bFGF in the synovial tissues of cacroiliac joint in the patients with active AS were stronger than those in pelvic fracture patients (P0.01). Conclusion BMP-2 and bFGF are the important factors in the process of pathological bone formation in patients with active AS. They are closely correlated with the process of bone formation in cacroiliac joint in active AS.

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