Objective  To study the effect of poly(ADP-ribose) polymerase (PARP) inhibitor 5-AIQ on the adhesion

migration and invasion of mouse colon adenocarcinoma cell line (CT26).   Methods  The expression of PARP after 5-AIQ treatment was detected Western blot. The cell adhesion

migration and invasion of CT26 after 5-AIQ treatment were observed by cell-matrix adhesion assay

cell migration assay and matrigel invasion assay.   Results  The expression of PARP in 5-AIQ-treated CT26 was weaker than that in 5-AIQ-untreated cells (P0.05). In the adhesion assay

the OD value of 5-AIQ-treated cells was reduced as compared with untreated cells (P0.05) and the inhibition rate of 100 μmol/L 5-AIQ treated cells and 500 μmol/L 5-AIQ treated cells was 14.54% and 21.69% respectively. Moreover

migration and invasion potential of CT26 were also reduced by 500 μmol/L 5-AIQ treatment (P0.05)

and the inhibition rate was 30.09% and 37.47% for migration and invasion respectively.   Conclusion  PARP inhibitor 5-AIQ can reduce the expression of PARP

adhesion

migration and invasion of CT26 cells

suggesting 5-AIQ probably plays a role against tumor metastasis.