Expressions of NF-κB and bcl-xL in draining lymph nodes of oral squamous cell carcinoma

余太平; 李勇; 王涛; 季平

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Expressions of NF-κB and bcl-xL in draining lymph nodes of oral squamous cell carcinoma

更新时间：2026-01-09

- Expressions of NF-κB and bcl-xL in draining lymph nodes of oral squamous cell carcinoma
- Journal of Army Medical University Vol. 30, Issue 2, Pages: 150-152(2008)
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  CLC： R394.3;R730.23;R739.8
- Published：2008
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余太平,李勇,王涛,季平.NF-κB及bcl-xL在口腔鳞癌引流淋巴结中的表达及意义[J].陆军军医大学学报(原第三军医大学学报),2008,30(02):150-152.

　YU Tai-ping,LI Yong,WANG Tao,JI Ping.Expressions of NF-κB and bcl-xL in draining lymph nodes of oral squamous cell carcinoma[J].J Amry Med Univ (J Third Mil Med Univ),2008,30(02):150-152.
余太平,李勇,王涛,季平.NF-κB及bcl-xL在口腔鳞癌引流淋巴结中的表达及意义[J].陆军军医大学学报(原第三军医大学学报),2008,30(02):150-152. DOI：

　YU Tai-ping,LI Yong,WANG Tao,JI Ping.Expressions of NF-κB and bcl-xL in draining lymph nodes of oral squamous cell carcinoma[J].J Amry Med Univ (J Third Mil Med Univ),2008,30(02):150-152. DOI：

摘要

目的研究核转录因子κB ( nuclear transcription factor kappα，NF-κB)及其靶基因bcl-xL在口腔鳞癌引流淋巴结（炎性淋巴结、转移性淋巴结）中的表达及意义。方法将所选口腔鳞癌病例引流淋巴结石蜡标本按病检结果分为炎性淋巴结组、转移性淋巴结组，应用免疫组织化学S-P法，检测NF-κB (p65)及bcl-xL在两组间的表达差异。结果 NF-κB (p65)在炎性淋巴结、转移性淋巴结中的阳性表达率分别为30.8%、76.9%，两组有显著性差异(P0.01)；bcl-xL在炎性淋巴结、转移性淋巴结中的阳性表达率分别为33.3%、73.1%，两组有显著性差异(P0.01)。结论口腔鳞癌引流淋巴结从炎性淋巴结向转移性淋巴结的转变可能和NF-κB、bcl-xL表达变化有关。

Abstract

ObjectiveTo investigate the expressions and the significance of NF-κB and its target gene bcl-xL in the draining lymph nodes of oral squamous cell carcinoma (OSCC). Methods Thirteen paraffin specimens of draining lymph nodes were divided into inflammatory lymph nodes and metastatic lymph nodes by pathological diagnosis. Immunohistochemistry (S-P method) was used to detect the expressions of NF-κB (p65) and bcl-xL. Results The positive rate of NF-κB (p65) was 30.8% in inflammatory lymph nodes

76.9% in metastatic lymph nodes (P0.01). The positive rate of bcl-xL was 33.3% in inflammatory lymph nodes

73.1% in metastatic lymph nodes (P0.01). Conclusion The progression from inflammatory lymph nodes of OSCC to metastatic ones may involve the expressions of NF-κB and bcl-xL.

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